ID   RAD9B_MOUSE             Reviewed;         403 AA.
AC   Q6WBX7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Cell cycle checkpoint control protein RAD9B;
DE   AltName: Full=DNA repair exonuclease rad9 homolog B;
DE            Short=mRAD9B;
GN   Name=Rad9b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Testis;
RX   PubMed=14500360;
RA   Hopkins K.M., Wang X., Berlin A., Hang H., Thaker H.M., Lieberman H.B.;
RT   "Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control
RT   genes in normal and cancerous testicular tissue.";
RL   Cancer Res. 63:5291-5298(2003).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354 AND SER-363, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Interacts with HUS1, HUS1B, RAD1, RAD9A and RAD17.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the rad9 family. {ECO:0000305}.
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DR   EMBL; AY297460; AAQ62860.1; -; mRNA.
DR   CCDS; CCDS19646.1; -.
DR   RefSeq; NP_659161.2; NM_144912.3.
DR   AlphaFoldDB; Q6WBX7; -.
DR   SMR; Q6WBX7; -.
DR   DIP; DIP-59316N; -.
DR   IntAct; Q6WBX7; 1.
DR   STRING; 10090.ENSMUSP00000036177; -.
DR   iPTMnet; Q6WBX7; -.
DR   PhosphoSitePlus; Q6WBX7; -.
DR   PaxDb; Q6WBX7; -.
DR   PRIDE; Q6WBX7; -.
DR   ProteomicsDB; 300389; -.
DR   Antibodypedia; 31019; 87 antibodies from 20 providers.
DR   DNASU; 231724; -.
DR   Ensembl; ENSMUST00000049009; ENSMUSP00000036177; ENSMUSG00000038569.
DR   GeneID; 231724; -.
DR   KEGG; mmu:231724; -.
DR   UCSC; uc008zkz.1; mouse.
DR   CTD; 144715; -.
DR   MGI; MGI:2385231; Rad9b.
DR   VEuPathDB; HostDB:ENSMUSG00000038569; -.
DR   eggNOG; KOG2810; Eukaryota.
DR   GeneTree; ENSGT00390000005767; -.
DR   HOGENOM; CLU_049242_2_0_1; -.
DR   InParanoid; Q6WBX7; -.
DR   OMA; HTKIWSE; -.
DR   OrthoDB; 1176140at2759; -.
DR   PhylomeDB; Q6WBX7; -.
DR   TreeFam; TF101212; -.
DR   Reactome; R-MMU-176187; Activation of ATR in response to replication stress.
DR   Reactome; R-MMU-5685938; HDR through Single Strand Annealing (SSA).
DR   Reactome; R-MMU-5693607; Processing of DNA double-strand break ends.
DR   Reactome; R-MMU-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-MMU-69473; G2/M DNA damage checkpoint.
DR   BioGRID-ORCS; 231724; 1 hit in 109 CRISPR screens.
DR   ChiTaRS; Rad9b; mouse.
DR   PRO; PR:Q6WBX7; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q6WBX7; protein.
DR   Bgee; ENSMUSG00000038569; Expressed in spermatocyte and 77 other tissues.
DR   ExpressionAtlas; Q6WBX7; baseline and differential.
DR   Genevisible; Q6WBX7; MM.
DR   GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR   InterPro; IPR026584; Rad9.
DR   InterPro; IPR007268; Rad9/Ddc1.
DR   PANTHER; PTHR15237; PTHR15237; 1.
DR   Pfam; PF04139; Rad9; 1.
DR   PIRSF; PIRSF009303; Cell_cycle_RAD9; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..403
FT                   /note="Cell cycle checkpoint control protein RAD9B"
FT                   /id="PRO_0000226700"
FT   REGION          285..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         354
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         363
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   403 AA;  44840 MW;  AB1A1D812E16B72F CRC64;
     MLKCGMTGGQ VKVFGKAVQT LSRVSDELWL DPSEKGLALR SVNSCHSTYG YVLFSSMFFQ
     HYQWSPFATM SDTDLPLNLN CKLAIKSVLP IFRCLNYLER SVEKCTVVAR ADKCRVVIQF
     FGKHGIKRTH NVYFQDSQPL KIIFEKSLCA NILMIKPRLL TEAIALLTSN QEEVTFSVTP
     GNFCLKSLSG ELLDLTSSVY SEMSFGPEEF DFFQVGLDTE ITFCFKELKG ILTFSEVMHA
     PLAIYFDFPG KPVVLSVEDM LLEANFILAT LVDYPSRTSS PQLLPLSQAR RSHPIQSSAP
     EDKSRVSQTP ESISRAAPKR LFPKDSPDSS SAAETKRASA GQDDIFEVPE SVVSDMEEER
     SPSHLRKFSC MFFGAVSCEQ QEYAGHPLDS LAVASDSEED VSG