ID   RADA_AERPX              Reviewed;         319 AA.
AC   P0CW91; Q8X233; Q8X263; Q8X264; Q8X265; Q8X266; Q8X267; Q9YFY1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=DNA repair and recombination protein RadA;
GN   Name=radA;
OS   Aeropyrum pernix.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=56636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=OH1, OH2, OH3, TB1, TB2, TB3, TB4, TB5, TB6, TB7, and TB8;
RA   Nomura N., Morinaga Y., Kogishi T., Kim E., Sako Y., Uchida A.;
RT   "Heterogeneous yet partially similar introns reside in identical positions
RT   of the rRNA genes in natural isolates of the archaeon Aeropyrum pernix.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in DNA repair and in homologous recombination. Binds
CC       and assemble on single-stranded DNA to form a nucleoprotein filament.
CC       Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand
CC       exchange between homologous DNA molecules (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB077994; BAB83900.1; -; Genomic_DNA.
DR   EMBL; AB077995; BAB83901.1; -; Genomic_DNA.
DR   EMBL; AB077996; BAB83902.1; -; Genomic_DNA.
DR   EMBL; AB077997; BAB83903.1; -; Genomic_DNA.
DR   EMBL; AB077998; BAB83904.1; -; Genomic_DNA.
DR   EMBL; AB077999; BAB83905.1; -; Genomic_DNA.
DR   EMBL; AB078000; BAB83906.1; -; Genomic_DNA.
DR   EMBL; AB078001; BAB83907.1; -; Genomic_DNA.
DR   EMBL; AB078002; BAB83908.1; -; Genomic_DNA.
DR   EMBL; AB078003; BAB83909.1; -; Genomic_DNA.
DR   EMBL; AB078004; BAB83910.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0CW91; -.
DR   SMR; P0CW91; -.
DR   PRIDE; P0CW91; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd01123; Rad51_DMC1_radA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00348; RadA_arch; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR011938; DNA_recomb/repair_RadA.
DR   InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033925; Rad51_DMC1_RadA.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   Pfam; PF08423; Rad51; 1.
DR   PIRSF; PIRSF005856; Rad51; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF47794; SSF47794; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02236; recomb_radA; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA recombination; DNA-binding;
KW   Nucleotide-binding.
FT   CHAIN           1..319
FT                   /note="DNA repair and recombination protein RadA"
FT                   /id="PRO_0000409306"
FT   BINDING         111..118
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VARIANT         5
FT                   /note="K -> N (in strain: TB2)"
FT   VARIANT         5
FT                   /note="K -> Q (in strain: TB1)"
FT   VARIANT         58
FT                   /note="I -> T (in strain: OH3)"
FT   VARIANT         201
FT                   /note="K -> R (in strain: OH2)"
FT   VARIANT         214
FT                   /note="A -> V (in strain: OH3)"
FT   VARIANT         286
FT                   /note="S -> G (in strain: TB1)"
FT   VARIANT         289
FT                   /note="N -> D (in strain: OH3)"
FT   VARIANT         289
FT                   /note="N -> S (in strain: TB2)"
FT   VARIANT         306
FT                   /note="T -> A (in strain: TB6)"
SQ   SEQUENCE   319 AA;  35334 MW;  AA2A3D273CA69546 CRC64;
     MGEDKREIKD ITDLPGVGPT TAQKLMEAGY TTLEAIAAAT PQEVSQATGI PILTAQKIVD
     AAREALNIDF KTAYDLKIES MNIKKITTGS RNLDELLGGG IETKTITELF GEFGSGKTQI
     CHQLSVNVQL PEDKGGLEGK AVYIDTEGTF RWERIEQMAR GVGLDPDEVM KNIYWIRAIN
     SHHQIAIVDK LFTMVKNDNI KLVVVDSVTS HFRAEFPGRE NLAMRQQLLN RHLHQLMRLA
     DIFNVAVVIT NQVMARPDVF YGDPTQAVGG HVLGHAPGVR VYLKKSRGNK RIARVVDAPH
     LPEGETVFAI TEWGIRDPE