ID   RADA_DESAM              Reviewed;         328 AA.
AC   Q9Y8J4;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA repair and recombination protein RadA;
GN   Name=radA;
OS   Desulfurococcus amylolyticus.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Desulfurococcus.
OX   NCBI_TaxID=94694;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3822 / JCM 9188 / Z-533;
RA   Kil Y.;
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in DNA repair and in homologous recombination. Binds
CC       and assemble on single-stranded DNA to form a nucleoprotein filament.
CC       Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand
CC       exchange between homologous DNA molecules (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF145465; AAD33955.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9Y8J4; -.
DR   SMR; Q9Y8J4; -.
DR   BRENDA; 3.6.4.B7; 1916.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd01123; Rad51_DMC1_radA; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00348; RadA_arch; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR011938; DNA_recomb/repair_RadA.
DR   InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR   InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR033925; Rad51_DMC1_RadA.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   InterPro; IPR020587; RecA_monomer-monomer_interface.
DR   Pfam; PF08423; Rad51; 1.
DR   PIRSF; PIRSF005856; Rad51; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF47794; SSF47794; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02236; recomb_radA; 1.
DR   PROSITE; PS50162; RECA_2; 1.
DR   PROSITE; PS50163; RECA_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA recombination; DNA-binding;
KW   Nucleotide-binding.
FT   CHAIN           1..328
FT                   /note="DNA repair and recombination protein RadA"
FT                   /id="PRO_0000150091"
FT   BINDING         118..125
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  36434 MW;  7F30A77DF55FC75E CRC64;
     MSEEKETIKE RSSGFISVRD IPGVGSSIAD KLEAAGYLSA WSIVVARAEE LAERTGLPVL
     TVQKIIENAR KMLGITFKTA REVKQERSNI GKITTGSKSL DELLGGGVET KTITEFFGEY
     GSGKTQICHQ LSVNVQLTPE KGGLNGRAVY IDTEGTFRWE RIEAMARALG LDPDKVMDNI
     YYMRAYNSDH QIAIVDELFT FVPKNDVRLV ILDSVTSHFR AEYPGREHLA ERQQKLNSHL
     HQLMRLAEAY NVAVVVTNQV MARPDVFYGD PTTAVGGHVL AHTPGVRIQL RKSKGNKRIA
     RVVDAPHLPE GEVVFVITEE GIRDSEEE