ID   RADB_PYRHO              Reviewed;         228 AA.
AC   O57859;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=DNA repair and recombination protein RadB;
GN   Name=radB; OrderedLocusNames=PH0119;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Involved in DNA repair and in homologous recombination. May
CC       regulate the cleavage reactions of the branch-structured DNA. Has a
CC       very weak ATPase activity that is not stimulated by DNA. Binds DNA but
CC       does not promote DNA strands exchange (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family. RadB
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29188.1; -; Genomic_DNA.
DR   PIR; E71232; E71232.
DR   RefSeq; WP_010884234.1; NC_000961.1.
DR   AlphaFoldDB; O57859; -.
DR   SMR; O57859; -.
DR   MINT; O57859; -.
DR   STRING; 70601.3256505; -.
DR   EnsemblBacteria; BAA29188; BAA29188; BAA29188.
DR   GeneID; 1444016; -.
DR   KEGG; pho:PH0119; -.
DR   eggNOG; arCOG00417; Archaea.
DR   OMA; GNTLEHW; -.
DR   OrthoDB; 93716at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00350; RadB; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR   InterPro; IPR011939; DNA_repair_and_recomb_RadB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020588; RecA_ATP-bd.
DR   Pfam; PF08423; Rad51; 1.
DR   PIRSF; PIRSF003336; RadB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02237; recomb_radB; 1.
DR   PROSITE; PS50162; RECA_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA recombination; DNA-binding;
KW   Nucleotide-binding.
FT   CHAIN           1..228
FT                   /note="DNA repair and recombination protein RadB"
FT                   /id="PRO_0000150118"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  25537 MW;  BE3E38E309DC8F6B CRC64;
     MKGSKSEVQG MVLTTGVKGL DELLGGGVAR RVILQVYGPF ATGKTTFAMQ VGLLNEGKVA
     YVDTEGGFSP ERLAQMARSR GLDPEKALSK FIIFEPMDLN EQRRVISKLK TIVDEKFSLV
     VVDSLTAHYR AEGSKNYGEL AKQLQVLQWL ARRKNVAVIV INQVYHDSNS NSLRPIAEHT
     LGYRTKDILR FEKLRVGVRL AVLERHRFRP EGGIVYFKIT DKGLEDSK