RADB_THESM
ID RADB_THESM Reviewed; 228 AA.
AC C6A0N1;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=DNA repair and recombination protein RadB {ECO:0000255|HAMAP-Rule:MF_00350};
GN Name=radB {ECO:0000255|HAMAP-Rule:MF_00350}; OrderedLocusNames=TSIB_0108;
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739;
RX PubMed=19447963; DOI=10.1128/aem.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
CC -!- FUNCTION: Involved in DNA repair and in homologous recombination. May
CC regulate the cleavage reactions of the branch-structured DNA. Has a
CC very weak ATPase activity that is not stimulated by DNA. Binds DNA but
CC does not promote DNA strands exchange. {ECO:0000255|HAMAP-
CC Rule:MF_00350}.
CC -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family. RadB
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00350}.
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DR EMBL; CP001463; ACS89176.1; -; Genomic_DNA.
DR RefSeq; WP_012766137.1; NC_012883.1.
DR AlphaFoldDB; C6A0N1; -.
DR SMR; C6A0N1; -.
DR STRING; 604354.TSIB_0108; -.
DR EnsemblBacteria; ACS89176; ACS89176; TSIB_0108.
DR GeneID; 8095077; -.
DR KEGG; tsi:TSIB_0108; -.
DR eggNOG; arCOG00417; Archaea.
DR HOGENOM; CLU_041732_2_0_2; -.
DR OMA; GNTLEHW; -.
DR OrthoDB; 93716at2157; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00350; RadB; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR011939; DNA_repair_and_recomb_RadB.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF003336; RadB; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02237; recomb_radB; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA recombination; DNA-binding;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..228
FT /note="DNA repair and recombination protein RadB"
FT /id="PRO_1000205340"
SQ SEQUENCE 228 AA; 25659 MW; 1B741020BA3F96E9 CRC64;
MLTTGSKNLD ALLGGGIDKG ILTQVYGPFA TGKTTLAMQI GLLNEGKVAY IDTEGGFSPE
RLAKMVESRG MDSNSTLQKF LIFEAFDFKE QKKTISNLKK IVNEKFSMIV VDSITNHYRV
EEKKSSMTTD LGKQLQVLLW LARKYNLAVI VTNQVYFDSK QNALKPLAEH IMGYKCKDIL
RLEKLRPGLR IAVLERHRFK PEGGIVHFEI TDKGIEDIEK IKSSQTTL