ID   RADE_FLOCH              Reviewed;         538 AA.
AC   C5H884;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Efflux pump radE {ECO:0000303|PubMed:19101477};
DE   AltName: Full=Radicicol biosynthesis cluster protein radE {ECO:0000303|PubMed:19101477};
GN   Name=radE {ECO:0000303|PubMed:19101477};
OS   Floropilus chiversii (Chaetomium chiversii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Floropilus.
OX   NCBI_TaxID=2587399;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=CS-36-62;
RX   PubMed=19101477; DOI=10.1016/j.chembiol.2008.10.006;
RA   Wang S., Xu Y., Maine E.A., Wijeratne E.M., Espinosa-Artiles P.,
RA   Gunatilaka A.A., Molnar I.;
RT   "Functional characterization of the biosynthesis of radicicol, an Hsp90
RT   inhibitor resorcylic acid lactone from Chaetomium chiversii.";
RL   Chem. Biol. 15:1328-1338(2008).
CC   -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC       radicicol or other secondary metabolies produced by the radicicol gene
CC       cluster (PubMed:19101477). {ECO:0000269|PubMed:19101477}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; EU980390; ACM42405.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5H884; -.
DR   SMR; C5H884; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..538
FT                   /note="Efflux pump radE"
FT                   /id="PRO_0000443056"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        482..502
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        505..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   538 AA;  58448 MW;  4EBE5C2BA7814FC2 CRC64;
     MATSRDFGRE PPRQQQDSDE AGHTLHDGCQ HVSEHPQIDV TAHDSSASAL PGDETTVGAA
     TAALDPKEEE RDPNIVDWDG PDDPANPQNW PPLKKWGNVA VLSIITFMVP LASSMFAPGI
     PQVLSDFDTN NPSLATFVVS VYILGLAAGP LVLAPMSELY GRVVIYHVGN VLFIIFTVAC
     ALSTNMNMLI AFRFLCGLVG AGPIAIGGGT IADLTTLQQR GTAMSVWSLG PLLGPSVGPV
     AGGFLSQAEG WRWIFWVLAI TAGVITIAGL LVLRETHPGT LLERKTRRLR KETGNMNLRS
     KLDLQVAPRT LFLRSIVRPS KLLVLSPICL VLSVYSAFVY AMIYFMISTF TFVFQDNYGF
     SEGIVGLVYI ALGLGMLFGV VVQQAIGNRI MKRLADKLNK GKPKPEYRIP PTLLAGFLIP
     TGLFIYGWTV QYHIQWAVPL LGALLAGMGI CIINISTNLY LVDAFTLYAA SALAASTVLR
     SIFGATFPLF ALQMYETLGL GWGNSLLAFI AVAMFAIPPL LFYYGERLRS HPRFQVKL