RADIL_HUMAN
ID RADIL_HUMAN Reviewed; 1075 AA.
AC Q96JH8; A4D1Z5; A5YM49; B7ZL20; Q0VFZ9; Q75LH3; Q9BSP5; Q9H0M6; Q9NW43;
AC Q9NWC4;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 5.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Ras-associating and dilute domain-containing protein;
GN Name=RADIL; Synonyms=KIAA1849;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ASN-239;
RP ASP-412 AND GLY-886.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 283-1075 (ISOFORM 1), AND VARIANTS ASP-412 AND
RP GLY-886.
RC TISSUE=Embryo, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANTS ASN-239;
RP ASP-412 AND GLY-886.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-886.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-886.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), AND VARIANTS
RP GLY-886 AND PRO-938.
RC TISSUE=Heart, Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-1075, AND VARIANT GLY-886.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [9]
RP FUNCTION, AND INTERACTION WITH RAP1A.
RX PubMed=17704304; DOI=10.1101/gad.1561507;
RA Smolen G.A., Schott B.J., Stewart R.A., Diederichs S., Muir B.,
RA Provencher H.L., Look A.T., Sgroi D.C., Peterson R.T., Haber D.A.;
RT "A Rap GTPase interactor, RADIL, mediates migration of neural crest
RT precursors.";
RL Genes Dev. 21:2131-2136(2007).
RN [10]
RP INTERACTION WITH KIF14.
RX PubMed=23209302; DOI=10.1083/jcb.201206051;
RA Ahmed S.M., Theriault B.L., Uppalapati M., Chiu C.W., Gallie B.L.,
RA Sidhu S.S., Angers S.;
RT "KIF14 negatively regulates Rap1a-Radil signaling during breast cancer
RT progression.";
RL J. Cell Biol. 199:951-967(2012).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206 AND SER-393, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP STRUCTURE BY NMR OF 973-1069.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of RSGI RUH-007, a PDZ domain.";
RL Submitted (MAR-2004) to the PDB data bank.
RN [13]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-239, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- FUNCTION: Downstream effector of Rap required for cell adhesion and
CC migration of neural crest precursors during development.
CC {ECO:0000269|PubMed:17704304}.
CC -!- SUBUNIT: Interacts with RAP1A; in a GTP-dependent manner. Does not
CC interact with members of the Ras family (PubMed:17704304). Interacts
CC (via PDZ domain) with KIF14; is recruited to the microtubule network
CC restricting its interaction with activated RAP1A (PubMed:23209302).
CC {ECO:0000269|PubMed:17704304, ECO:0000269|PubMed:23209302}.
CC -!- INTERACTION:
CC Q96JH8; P02654: APOC1; NbExp=3; IntAct=EBI-744267, EBI-1220105;
CC Q96JH8; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-744267, EBI-742887;
CC Q96JH8; P15976: GATA1; NbExp=3; IntAct=EBI-744267, EBI-3909284;
CC Q96JH8; Q15323: KRT31; NbExp=6; IntAct=EBI-744267, EBI-948001;
CC Q96JH8; P43364-2: MAGEA11; NbExp=3; IntAct=EBI-744267, EBI-10178634;
CC Q96JH8; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-744267, EBI-748896;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=4;
CC IsoId=Q96JH8-4; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96JH8-2; Sequence=VSP_016098;
CC Name=3;
CC IsoId=Q96JH8-3; Sequence=VSP_016097, VSP_016099;
CC Name=1;
CC IsoId=Q96JH8-1; Sequence=VSP_035179;
CC -!- SIMILARITY: Belongs to the RADIL family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS07559.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAA91543.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB47478.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB058752; BAB47478.1; ALT_INIT; mRNA.
DR EMBL; AK000997; BAA91459.1; -; mRNA.
DR EMBL; AK001186; BAA91543.1; ALT_INIT; mRNA.
DR EMBL; EF560723; ABQ59033.1; -; mRNA.
DR EMBL; AC092610; AAS07559.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH236953; EAL23966.1; -; Genomic_DNA.
DR EMBL; CH471144; EAW87301.1; -; Genomic_DNA.
DR EMBL; BC004919; AAH04919.2; -; mRNA.
DR EMBL; BC117317; AAI17318.1; -; mRNA.
DR EMBL; BC126311; AAI26312.1; -; mRNA.
DR EMBL; BC143526; AAI43527.1; -; mRNA.
DR EMBL; AL136731; CAB66665.2; -; mRNA.
DR CCDS; CCDS43544.1; -. [Q96JH8-4]
DR RefSeq; NP_060529.4; NM_018059.4. [Q96JH8-4]
DR PDB; 1UM1; NMR; -; A=973-1069.
DR PDB; 3EC8; X-ray; 2.60 A; A=51-193.
DR PDBsum; 1UM1; -.
DR PDBsum; 3EC8; -.
DR AlphaFoldDB; Q96JH8; -.
DR SMR; Q96JH8; -.
DR BioGRID; 120823; 39.
DR IntAct; Q96JH8; 21.
DR MINT; Q96JH8; -.
DR STRING; 9606.ENSP00000382492; -.
DR iPTMnet; Q96JH8; -.
DR PhosphoSitePlus; Q96JH8; -.
DR BioMuta; RADIL; -.
DR DMDM; 317373589; -.
DR MassIVE; Q96JH8; -.
DR PaxDb; Q96JH8; -.
DR PeptideAtlas; Q96JH8; -.
DR PRIDE; Q96JH8; -.
DR ProteomicsDB; 76964; -. [Q96JH8-4]
DR ProteomicsDB; 76965; -. [Q96JH8-1]
DR ProteomicsDB; 76966; -. [Q96JH8-2]
DR ProteomicsDB; 76967; -. [Q96JH8-3]
DR Antibodypedia; 43694; 148 antibodies from 20 providers.
DR DNASU; 55698; -.
DR Ensembl; ENST00000399583.4; ENSP00000382492.3; ENSG00000157927.17. [Q96JH8-4]
DR GeneID; 55698; -.
DR KEGG; hsa:55698; -.
DR MANE-Select; ENST00000399583.4; ENSP00000382492.3; NM_018059.5; NP_060529.4.
DR UCSC; uc003snj.2; human. [Q96JH8-4]
DR CTD; 55698; -.
DR DisGeNET; 55698; -.
DR GeneCards; RADIL; -.
DR HGNC; HGNC:22226; RADIL.
DR HPA; ENSG00000157927; Tissue enhanced (brain).
DR MIM; 611491; gene.
DR neXtProt; NX_Q96JH8; -.
DR OpenTargets; ENSG00000157927; -.
DR PharmGKB; PA164725261; -.
DR VEuPathDB; HostDB:ENSG00000157927; -.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000159293; -.
DR HOGENOM; CLU_010386_0_0_1; -.
DR InParanoid; Q96JH8; -.
DR OMA; CIPFQNE; -.
DR OrthoDB; 447883at2759; -.
DR PhylomeDB; Q96JH8; -.
DR TreeFam; TF350641; -.
DR PathwayCommons; Q96JH8; -.
DR SignaLink; Q96JH8; -.
DR BioGRID-ORCS; 55698; 17 hits in 1075 CRISPR screens.
DR ChiTaRS; RADIL; human.
DR EvolutionaryTrace; Q96JH8; -.
DR GeneWiki; RADIL; -.
DR GenomeRNAi; 55698; -.
DR Pharos; Q96JH8; Tbio.
DR PRO; PR:Q96JH8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96JH8; protein.
DR Bgee; ENSG00000157927; Expressed in oocyte and 148 other tissues.
DR ExpressionAtlas; Q96JH8; baseline and differential.
DR Genevisible; Q96JH8; HS.
DR GO; GO:0005874; C:microtubule; IDA:MGI.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0051020; F:GTPase binding; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:MGI.
DR CDD; cd15472; Myo5p-like_CBD_Rasip1; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR037983; CBD_Rasip1/Radil.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell adhesion; Developmental protein;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1075
FT /note="Ras-associating and dilute domain-containing
FT protein"
FT /id="PRO_0000050803"
FT DOMAIN 61..164
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT DOMAIN 314..389
FT /note="FHA"
FT DOMAIN 497..764
FT /note="Dilute"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00503"
FT DOMAIN 976..1061
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 183..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 216
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q69Z89"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q69Z89"
FT MOD_RES 221
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q69Z89"
FT MOD_RES 393
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 890
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q69Z89"
FT VAR_SEQ 1..704
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016097"
FT VAR_SEQ 1..495
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016098"
FT VAR_SEQ 262..279
FT /note="DSLVYVLNRDRHTVGQRT -> PGVCAQPGPAHGGPAD (in isoform
FT 1)"
FT /evidence="ECO:0000303|PubMed:11347906,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_035179"
FT VAR_SEQ 705..763
FT /note="ATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQD
FT SPEAFRS -> MSPRVGPVTVARIPASCVHRAGDSGLNLLAPGFPHRWAGRPGEGGSFS
FT CGHYGHPLSPA (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016099"
FT VARIANT 239
FT /note="D -> N (in dbSNP:rs3763384)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:17974005, ECO:0007744|PubMed:19690332"
FT /id="VAR_046192"
FT VARIANT 412
FT /note="H -> D (in dbSNP:rs2292498)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:17974005"
FT /id="VAR_046193"
FT VARIANT 886
FT /note="S -> G (in dbSNP:rs414035)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:11347906, ECO:0000269|PubMed:12690205,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.6"
FT /id="VAR_023769"
FT VARIANT 938
FT /note="L -> P (in dbSNP:rs6966329)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060193"
FT CONFLICT 700
FT /note="T -> I (in Ref. 8; CAB66665)"
FT /evidence="ECO:0000305"
FT HELIX 52..60
FT /evidence="ECO:0007829|PDB:3EC8"
FT STRAND 62..68
FT /evidence="ECO:0007829|PDB:3EC8"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:3EC8"
FT HELIX 89..99
FT /evidence="ECO:0007829|PDB:3EC8"
FT HELIX 104..109
FT /evidence="ECO:0007829|PDB:3EC8"
FT STRAND 110..117
FT /evidence="ECO:0007829|PDB:3EC8"
FT STRAND 130..133
FT /evidence="ECO:0007829|PDB:3EC8"
FT HELIX 140..146
FT /evidence="ECO:0007829|PDB:3EC8"
FT STRAND 154..161
FT /evidence="ECO:0007829|PDB:3EC8"
FT HELIX 162..188
FT /evidence="ECO:0007829|PDB:3EC8"
FT STRAND 974..980
FT /evidence="ECO:0007829|PDB:1UM1"
FT STRAND 988..992
FT /evidence="ECO:0007829|PDB:1UM1"
FT TURN 993..995
FT /evidence="ECO:0007829|PDB:1UM1"
FT STRAND 1001..1008
FT /evidence="ECO:0007829|PDB:1UM1"
FT HELIX 1013..1017
FT /evidence="ECO:0007829|PDB:1UM1"
FT STRAND 1025..1031
FT /evidence="ECO:0007829|PDB:1UM1"
FT HELIX 1039..1047
FT /evidence="ECO:0007829|PDB:1UM1"
FT STRAND 1051..1058
FT /evidence="ECO:0007829|PDB:1UM1"
FT HELIX 1062..1068
FT /evidence="ECO:0007829|PDB:1UM1"
SQ SEQUENCE 1075 AA; 117455 MW; A071219E8FD10131 CRC64;
MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD DPAELSTQLS
APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY ALDPRQAGQY VLCDVVGQAG
DAGQRWQARC FRVFGDSEKP LLIQELWKPR EGLSRRFELR KRSDVEELAA KEVDTITAGI
NAQARRLQRS RAKGTPTPAL GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA
MRYSLYQSPH LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI
RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY YLLLFKDPAQ
AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP RRQQLLLEFE PHLEDTLLQR
IMTLIEPGGD DHKLTPAFLL CLCIQHSATH FQPGTFGQLL LKIARLIRET VWEKTKELAE
KQAQLQEPIS LASCAMADLV PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS
KESLFSCTLT ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS
SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN QLLDRGPSLS
CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT LNLLATPRAQ LIQMSWTALR
AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW EPGAQDSPEA FRSEDVLESY ENPPPIVLPS
DGFQVDLEAN CLDDSIYQHL LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL
DGHLEAPSCP LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS
CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS AALAEESPPA
PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA PGLYIQTLLP GSPAAADGRL
SLGDRILEVN GSSLLGLGYL RAVDLIRHGG KKMRFLVAKS DVETAKKIHF RTPPL
