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RAD_ANTMA
ID   RAD_ANTMA               Reviewed;          93 AA.
AC   Q58FS3;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Transcription factor RADIALIS;
GN   Name=RAD;
OS   Antirrhinum majus (Garden snapdragon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Antirrhinum.
OX   NCBI_TaxID=4151;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION, DISRUPTION
RP   PHENOTYPE, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=15790677; DOI=10.1073/pnas.0501340102;
RA   Corley S.B., Carpenter R., Copsey L., Coen E.;
RT   "Floral asymmetry involves an interplay between TCP and MYB transcription
RT   factors in Antirrhinum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:5068-5073(2005).
RN   [2]
RP   INDUCTION.
RX   PubMed=16236768; DOI=10.1242/dev.02085;
RA   Costa M.M., Fox S., Hanna A.I., Baxter C., Coen E.;
RT   "Evolution of regulatory interactions controlling floral asymmetry.";
RL   Development 132:5093-5101(2005).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
RX   PubMed=17044043; DOI=10.1002/prot.21136;
RA   Stevenson C.E., Burton N., Costa M.M., Nath U., Dixon R.A., Coen E.S.,
RA   Lawson D.M.;
RT   "Crystal structure of the MYB domain of the RAD transcription factor from
RT   Antirrhinum majus.";
RL   Proteins 65:1041-1045(2006).
CC   -!- FUNCTION: Involved in the dorsovental asymmetry of flowers. Promotes
CC       dorsal identity. {ECO:0000269|PubMed:15790677}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in the dorsal region of
CC       developing flowers. {ECO:0000269|PubMed:15790677}.
CC   -!- DEVELOPMENTAL STAGE: Early expressed at stage two (plastochrons 7 and
CC       8), when the floral meristem comprised a loaf-shaped bulge of cells.
CC       Expression was in the dorsal region of the floral meristem. At stage
CC       four, when sepal primordia had emerged around the meristem dome,
CC       expression could be seen in the dorsal sepal primordium. At stage five,
CC       expressed in emerging dorsal primordia of whorls two and three. In
CC       older flower buds (stages seven and eight), expression was found mainly
CC       in the dorsal petals and staminode. {ECO:0000269|PubMed:15790677}.
CC   -!- INDUCTION: Up-regulated by both CYC and DICH.
CC       {ECO:0000269|PubMed:15790677, ECO:0000269|PubMed:16236768}.
CC   -!- DISRUPTION PHENOTYPE: Radially symmetric flowers. Loss of functional
CC       stamens in dorsal positions. Organs reduction with five organs per
CC       whorl rather than six. {ECO:0000269|PubMed:15790677}.
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DR   EMBL; AY954971; AAX48042.1; -; Genomic_DNA.
DR   PDB; 2CJJ; X-ray; 1.90 A; A=1-93.
DR   PDBsum; 2CJJ; -.
DR   AlphaFoldDB; Q58FS3; -.
DR   SMR; Q58FS3; -.
DR   EvolutionaryTrace; Q58FS3; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0048262; P:determination of dorsal/ventral asymmetry; IMP:UniProtKB.
DR   GO; GO:0009908; P:flower development; IMP:UniProtKB.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR044636; RADIALIS-like.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   PANTHER; PTHR43952; PTHR43952; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Developmental protein; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..93
FT                   /note="Transcription factor RADIALIS"
FT                   /id="PRO_0000419439"
FT   DOMAIN          6..61
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   HELIX           13..25
FT                   /evidence="ECO:0007829|PDB:2CJJ"
FT   HELIX           33..40
FT                   /evidence="ECO:0007829|PDB:2CJJ"
FT   HELIX           46..65
FT                   /evidence="ECO:0007829|PDB:2CJJ"
SQ   SEQUENCE   93 AA;  10774 MW;  A89972705EE53AEF CRC64;
     MASTRGSGRP WSAKENKAFE RALAVYDKDT PDRWANVARA VEGRTPEEVK KHYEILVEDI
     KYIESGKVPF PNYRTTGGNM KTDEKRFRNL KIR
 
 
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