RAE1L_BOVIN
ID RAE1L_BOVIN Reviewed; 368 AA.
AC Q5E9A4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=mRNA export factor;
DE AltName: Full=Rae1 protein homolog;
DE AltName: Full=mRNA-associated protein mrnp 41;
GN Name=RAE1; Synonyms=MRNP41;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in mitotic bipolar spindle formation. Binds
CC mRNA. May function in nucleocytoplasmic transport and in directly or
CC indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
CC {ECO:0000250|UniProtKB:P78406}.
CC -!- SUBUNIT: Interacts with NUMA1 (via N-terminal end of the coiled-coil
CC domain); this interaction promotes spindle formation in mitosis (By
CC similarity). Interacts with NUP98 (By similarity). Interacts with
CC MYCBP2 (By similarity). Interacts with USP11 (By similarity).
CC {ECO:0000250|UniProtKB:P78406}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus
CC {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250|UniProtKB:P78406}. Note=Recruited from interphase nuclei
CC to spindle MTs during mitosis. {ECO:0000250|UniProtKB:P78406}.
CC -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR EMBL; BT021016; AAX09033.1; -; mRNA.
DR EMBL; BC111248; AAI11249.1; -; mRNA.
DR RefSeq; NP_001015585.1; NM_001015585.1.
DR AlphaFoldDB; Q5E9A4; -.
DR SMR; Q5E9A4; -.
DR STRING; 9913.ENSBTAP00000014523; -.
DR PaxDb; Q5E9A4; -.
DR PRIDE; Q5E9A4; -.
DR Ensembl; ENSBTAT00000014523; ENSBTAP00000014523; ENSBTAG00000010934.
DR GeneID; 513080; -.
DR KEGG; bta:513080; -.
DR CTD; 8480; -.
DR VEuPathDB; HostDB:ENSBTAG00000010934; -.
DR VGNC; VGNC:33692; RAE1.
DR eggNOG; KOG0647; Eukaryota.
DR GeneTree; ENSGT00950000183091; -.
DR HOGENOM; CLU_038526_1_0_1; -.
DR InParanoid; Q5E9A4; -.
DR OMA; EAMDQSI; -.
DR OrthoDB; 1048963at2759; -.
DR TreeFam; TF105481; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000010934; Expressed in oocyte and 106 other tissues.
DR ExpressionAtlas; Q5E9A4; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037631; Gle2/RAE1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..368
FT /note="mRNA export factor"
FT /id="PRO_0000237585"
FT REPEAT 37..79
FT /note="WD 1"
FT REPEAT 84..114
FT /note="WD 2"
FT REPEAT 125..157
FT /note="WD 3"
FT REPEAT 168..206
FT /note="WD 4"
FT REPEAT 215..255
FT /note="WD 5"
FT REPEAT 271..301
FT /note="WD 6"
FT REPEAT 310..346
FT /note="WD 7"
FT REGION 15..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 229
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P78406"
SQ SEQUENCE 368 AA; 40967 MW; CF7E4261CB5926EB CRC64;
MSLFGTTSGF GSGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG
SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLNSNQA
IQIAQHDAPV KTVHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY
PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV
AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE
ELKPRNKK
