RAE1L_DANRE
ID RAE1L_DANRE Reviewed; 368 AA.
AC Q7ZWF0; Q6P037;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=mRNA export factor;
DE AltName: Full=Rae1 protein homolog;
DE AltName: Full=mRNA-associated protein mrnp 41;
GN Name=rae1; Synonyms=mrnp41;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in mitotic bipolar spindle formation. Binds
CC mRNA. May function in nucleocytoplasmic transport and in directly or
CC indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
CC {ECO:0000250|UniProtKB:P78406}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus
CC {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250|UniProtKB:P78406}.
CC -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR EMBL; BC049445; AAH49445.1; -; mRNA.
DR EMBL; BC065853; AAH65853.1; -; mRNA.
DR RefSeq; NP_957292.1; NM_200998.1.
DR AlphaFoldDB; Q7ZWF0; -.
DR SMR; Q7ZWF0; -.
DR STRING; 7955.ENSDARP00000015105; -.
DR PaxDb; Q7ZWF0; -.
DR Ensembl; ENSDART00000020333; ENSDARP00000015105; ENSDARG00000007196.
DR GeneID; 393973; -.
DR KEGG; dre:393973; -.
DR CTD; 8480; -.
DR ZFIN; ZDB-GENE-040426-1029; rae1.
DR eggNOG; KOG0647; Eukaryota.
DR GeneTree; ENSGT00950000183091; -.
DR HOGENOM; CLU_038526_1_0_1; -.
DR InParanoid; Q7ZWF0; -.
DR OMA; EAMDQSI; -.
DR OrthoDB; 1048963at2759; -.
DR PhylomeDB; Q7ZWF0; -.
DR TreeFam; TF105481; -.
DR Reactome; R-DRE-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-DRE-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-DRE-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DRE-191859; snRNP Assembly.
DR Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DRE-3232142; SUMOylation of ubiquitinylation proteins.
DR Reactome; R-DRE-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR PRO; PR:Q7ZWF0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000007196; Expressed in testis and 29 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR037631; Gle2/RAE1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..368
FT /note="mRNA export factor"
FT /id="PRO_0000312982"
FT REPEAT 37..79
FT /note="WD 1"
FT REPEAT 84..114
FT /note="WD 2"
FT REPEAT 125..157
FT /note="WD 3"
FT REPEAT 168..206
FT /note="WD 4"
FT REPEAT 215..255
FT /note="WD 5"
FT REPEAT 271..301
FT /note="WD 6"
FT REPEAT 310..346
FT /note="WD 7"
FT REGION 15..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 40
FT /note="D -> E (in Ref. 1; AAH49445)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 368 AA; 41051 MW; 0A9FAD27C9291BF7 CRC64;
MSLFGTNTGF GSGGTGVFGS TTTDSHNPMK DVEVTSPPDD SISCLAFSPP TMPGNFLIGG
SWANDVRCWE VQDNGQTVPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLNSNQA
IQIAQHEGPI RTIHWIKAPN YSCIMTGSWD KTLKFWDTRS PNPMMSLQMP ERCYCADVVY
PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQSKPTG FALGSIEGRV
AIHYINPPNP AKDNFTFKCH RSNGTNTATP QDIYAVNAIS FHPVHGTLAT VGSDGRFSFW
DKDARTKLKT SEQLDQPITA CCFNHNGNIF AYASSYDWSK GHEYYNPQKK NYIFLRNAAE
ELKPRNKK
