ID   RAE1L_MACFA             Reviewed;         368 AA.
AC   Q4R6D2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=mRNA export factor;
DE   AltName: Full=Rae1 protein homolog;
DE   AltName: Full=mRNA-associated protein mrnp 41;
GN   Name=RAE1; Synonyms=MRNP41; ORFNames=QtsA-18247;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitotic bipolar spindle formation. Binds
CC       mRNA. May function in nucleocytoplasmic transport and in directly or
CC       indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SUBUNIT: Interacts with NUMA1 (via N-terminal end of the coiled-coil
CC       domain); this interaction promotes spindle formation in mitosis (By
CC       similarity). Interacts with NUP98 (By similarity). Interacts with
CC       MYCBP2 (By similarity). Interacts with USP11 (By similarity).
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus
CC       {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:P78406}. Note=Recruited from interphase nuclei
CC       to spindle MTs during mitosis. {ECO:0000250|UniProtKB:P78406}.
CC   -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR   EMBL; AB169253; BAE01343.1; -; mRNA.
DR   RefSeq; NP_001271046.1; NM_001284117.1.
DR   AlphaFoldDB; Q4R6D2; -.
DR   SMR; Q4R6D2; -.
DR   STRING; 9541.XP_005569476.1; -.
DR   GeneID; 101864841; -.
DR   CTD; 8480; -.
DR   eggNOG; KOG0647; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037631; Gle2/RAE1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..368
FT                   /note="mRNA export factor"
FT                   /id="PRO_0000266024"
FT   REPEAT          37..79
FT                   /note="WD 1"
FT   REPEAT          84..114
FT                   /note="WD 2"
FT   REPEAT          125..157
FT                   /note="WD 3"
FT   REPEAT          168..206
FT                   /note="WD 4"
FT   REPEAT          215..255
FT                   /note="WD 5"
FT   REPEAT          271..301
FT                   /note="WD 6"
FT   REPEAT          310..346
FT                   /note="WD 7"
FT   REGION          15..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         229
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P78406"
SQ   SEQUENCE   368 AA;  40956 MW;  2F3B82CE3038D338 CRC64;
     MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG
     SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLSSNQA
     IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERYYCADVIY
     PMAVVATAGR GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV
     AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
     DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE
     ELKPRNKK