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RAE1L_RAT
ID   RAE1L_RAT               Reviewed;         368 AA.
AC   Q3SWS8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=mRNA export factor;
DE   AltName: Full=Rae1 protein homolog;
DE   AltName: Full=mRNA-associated protein mrnp 41;
GN   Name=Rae1; Synonyms=Mrnp41;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate, and Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   INTERACTION WITH MYCBP2.
RX   PubMed=22357847; DOI=10.1523/jneurosci.2901-11.2012;
RA   Grill B., Chen L., Tulgren E.D., Baker S.T., Bienvenut W., Anderson M.,
RA   Quadroni M., Jin Y., Garner C.C.;
RT   "RAE-1, a novel PHR binding protein, is required for axon termination and
RT   synapse formation in Caenorhabditis elegans.";
RL   J. Neurosci. 32:2628-2636(2012).
CC   -!- FUNCTION: Plays a role in mitotic bipolar spindle formation. Binds
CC       mRNA. May function in nucleocytoplasmic transport and in directly or
CC       indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SUBUNIT: Interacts with NUMA1 (via N-terminal end of the coiled-coil
CC       domain); this interaction promotes spindle formation in mitosis (By
CC       similarity). Interacts with NUP98 (By similarity). Interacts with
CC       MYCBP2 (PubMed:22357847). Interacts with USP11 (By similarity).
CC       {ECO:0000250|UniProtKB:P78406, ECO:0000269|PubMed:22357847}.
CC   -!- INTERACTION:
CC       Q3SWS8; O75592: MYCBP2; Xeno; NbExp=2; IntAct=EBI-6920222, EBI-1043774;
CC       Q3SWS8; Q17551: rpm-1; Xeno; NbExp=2; IntAct=EBI-6920222, EBI-6920110;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus
CC       {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:P78406}. Note=Recruited from interphase nuclei
CC       to spindle MTs during mitosis. {ECO:0000250|UniProtKB:P78406}.
CC   -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR   EMBL; BC104721; AAI04722.1; -; mRNA.
DR   EMBL; BC105758; AAI05759.1; -; mRNA.
DR   RefSeq; NP_001028880.1; NM_001033708.1.
DR   RefSeq; XP_008760741.1; XM_008762519.2.
DR   AlphaFoldDB; Q3SWS8; -.
DR   SMR; Q3SWS8; -.
DR   BioGRID; 263329; 1.
DR   CORUM; Q3SWS8; -.
DR   IntAct; Q3SWS8; 2.
DR   STRING; 10116.ENSRNOP00000029085; -.
DR   jPOST; Q3SWS8; -.
DR   PaxDb; Q3SWS8; -.
DR   PRIDE; Q3SWS8; -.
DR   Ensembl; ENSRNOT00000038182; ENSRNOP00000029085; ENSRNOG00000021295.
DR   GeneID; 362281; -.
DR   KEGG; rno:362281; -.
DR   UCSC; RGD:1311540; rat.
DR   CTD; 8480; -.
DR   RGD; 1311540; Rae1.
DR   eggNOG; KOG0647; Eukaryota.
DR   GeneTree; ENSGT00950000183091; -.
DR   HOGENOM; CLU_038526_1_0_1; -.
DR   InParanoid; Q3SWS8; -.
DR   OMA; EAMDQSI; -.
DR   OrthoDB; 1048963at2759; -.
DR   PhylomeDB; Q3SWS8; -.
DR   TreeFam; TF105481; -.
DR   Reactome; R-RNO-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-RNO-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-RNO-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-RNO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-RNO-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
DR   Reactome; R-RNO-191859; snRNP Assembly.
DR   Reactome; R-RNO-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-RNO-3232142; SUMOylation of ubiquitinylation proteins.
DR   Reactome; R-RNO-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-RNO-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-RNO-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-RNO-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-RNO-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-RNO-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-RNO-5578749; Transcriptional regulation by small RNAs.
DR   PRO; PR:Q3SWS8; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000021295; Expressed in thymus and 19 other tissues.
DR   Genevisible; Q3SWS8; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR   GO; GO:0005635; C:nuclear envelope; IDA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; ISO:RGD.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:RGD.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037631; Gle2/RAE1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..368
FT                   /note="mRNA export factor"
FT                   /id="PRO_0000237587"
FT   REPEAT          37..79
FT                   /note="WD 1"
FT   REPEAT          84..114
FT                   /note="WD 2"
FT   REPEAT          125..157
FT                   /note="WD 3"
FT   REPEAT          168..206
FT                   /note="WD 4"
FT   REPEAT          215..255
FT                   /note="WD 5"
FT   REPEAT          271..301
FT                   /note="WD 6"
FT   REPEAT          310..346
FT                   /note="WD 7"
FT   REGION          15..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         229
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P78406"
SQ   SEQUENCE   368 AA;  40919 MW;  90EE24DCE33D7648 CRC64;
     MSLFGTTSGF GTGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG
     SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLNSNQA
     IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY
     PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV
     AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
     DKDARTKLKT SEQLDQPVAA CGFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE
     ELKPRNKK
 
 
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