ID   RAE1L_XENTR             Reviewed;         368 AA.
AC   Q5FVA9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=mRNA export factor;
DE   AltName: Full=Rae1 protein homolog;
DE   AltName: Full=mRNA-associated protein mrnp 41;
GN   Name=rae1; Synonyms=mrnp41; ORFNames=TEgg053e05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitotic bipolar spindle formation. Binds
CC       mRNA. May function in nucleocytoplasmic transport and in directly or
CC       indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus
CC       {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR   EMBL; CR760979; CAJ82097.1; -; mRNA.
DR   EMBL; BC090109; AAH90109.1; -; mRNA.
DR   RefSeq; NP_001017142.1; NM_001017142.2.
DR   AlphaFoldDB; Q5FVA9; -.
DR   SMR; Q5FVA9; -.
DR   GeneID; 549896; -.
DR   KEGG; xtr:549896; -.
DR   CTD; 8480; -.
DR   Xenbase; XB-GENE-995595; rae1.
DR   InParanoid; Q5FVA9; -.
DR   OrthoDB; 1048963at2759; -.
DR   Reactome; R-XTR-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-XTR-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-XTR-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-XTR-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-XTR-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-XTR-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-XTR-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-XTR-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-XTR-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-XTR-5578749; Transcriptional regulation by small RNAs.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR   GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037631; Gle2/RAE1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW   Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..368
FT                   /note="mRNA export factor"
FT                   /id="PRO_0000312983"
FT   REPEAT          37..79
FT                   /note="WD 1"
FT   REPEAT          84..114
FT                   /note="WD 2"
FT   REPEAT          125..157
FT                   /note="WD 3"
FT   REPEAT          168..206
FT                   /note="WD 4"
FT   REPEAT          215..255
FT                   /note="WD 5"
FT   REPEAT          271..301
FT                   /note="WD 6"
FT   REPEAT          310..346
FT                   /note="WD 7"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  40948 MW;  ADC3FD3B13E94455 CRC64;
     MSLFSTPGGF GTGGGSMFGS TATDNHNPMK DIEVTSPPDD SISCLSFSPP TLPGNFLIAG
     SWANDVRCWE VQDNGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLNSNQS
     IQIAQHDAPI KTVHWVKAPN YSCIMTGSWD KSLKFWDTRS PNPLLTLQLP ERCYCADVVY
     PMAVVATAER GLIVYQLENQ PSEFRRIDSP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV
     AIHYINPPNP AKDNFTFKCH RSNGTNTTAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
     DKDARTKLKT SEQLDQPISA CSFNHNGNIF AYSSSYDWSK GHEFYNPQKK NYIFLRNAAE
     ELKPRNKK