ID   RAEL1_PONAB             Reviewed;         368 AA.
AC   Q5RF99;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=mRNA export factor;
DE   AltName: Full=Rae1 protein homolog;
DE   AltName: Full=mRNA-associated protein mrnp 41;
GN   Name=RAE1; Synonyms=MRNP41;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitotic bipolar spindle formation. Binds
CC       mRNA. May function in nucleocytoplasmic transport and in directly or
CC       indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SUBUNIT: Interacts with NUMA1 (via N-terminal end of the coiled-coil
CC       domain); this interaction promotes spindle formation in mitosis (By
CC       similarity). Interacts with NUP98 (By similarity). Interacts with
CC       MYCBP2 (By similarity). Interacts with USP11 (By similarity).
CC       {ECO:0000250|UniProtKB:P78406}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P78406}. Nucleus
CC       {ECO:0000250|UniProtKB:P78406}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:P78406}. Note=Recruited from interphase nuclei
CC       to spindle MTs during mitosis. {ECO:0000250|UniProtKB:P78406}.
CC   -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR   EMBL; CR857262; CAH89558.1; -; mRNA.
DR   RefSeq; NP_001124680.1; NM_001131208.1.
DR   AlphaFoldDB; Q5RF99; -.
DR   SMR; Q5RF99; -.
DR   STRING; 9601.ENSPPYP00000012468; -.
DR   Ensembl; ENSPPYT00000012956; ENSPPYP00000012468; ENSPPYG00000011159.
DR   GeneID; 100171527; -.
DR   KEGG; pon:100171527; -.
DR   CTD; 8480; -.
DR   eggNOG; KOG0647; Eukaryota.
DR   GeneTree; ENSGT00950000183091; -.
DR   HOGENOM; CLU_038526_1_0_1; -.
DR   InParanoid; Q5RF99; -.
DR   OMA; EAMDQSI; -.
DR   OrthoDB; 1048963at2759; -.
DR   TreeFam; TF105481; -.
DR   Proteomes; UP000001595; Chromosome 20.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097431; C:mitotic spindle pole; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR037631; Gle2/RAE1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..368
FT                   /note="mRNA export factor"
FT                   /id="PRO_0000312981"
FT   REPEAT          37..79
FT                   /note="WD 1"
FT   REPEAT          84..114
FT                   /note="WD 2"
FT   REPEAT          125..157
FT                   /note="WD 3"
FT   REPEAT          168..206
FT                   /note="WD 4"
FT   REPEAT          215..255
FT                   /note="WD 5"
FT   REPEAT          271..301
FT                   /note="WD 6"
FT   REPEAT          310..346
FT                   /note="WD 7"
FT   REGION          15..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         229
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P78406"
SQ   SEQUENCE   368 AA;  40968 MW;  89A99C34BA668A97 CRC64;
     MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG
     SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLSSNQA
     IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY
     PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV
     AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
     DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE
     ELKPRNKK