AAEB_SALTI
ID AAEB_SALTI Reviewed; 655 AA.
AC Q8Z3D8; Q7C6X9;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule:MF_01545};
DE Short=pHBA efflux pump protein B {ECO:0000255|HAMAP-Rule:MF_01545};
GN Name=aaeB {ECO:0000255|HAMAP-Rule:MF_01545};
GN OrderedLocusNames=STY3545, t3279;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Forms an efflux pump with AaeA. Could function as a metabolic
CC relief valve, allowing to eliminate certain compounds when they
CC accumulate to high levels in the cell. {ECO:0000255|HAMAP-
CC Rule:MF_01545}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01545}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01545}.
CC -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC family. {ECO:0000255|HAMAP-Rule:MF_01545}.
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DR EMBL; AL513382; CAD07879.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70814.1; -; Genomic_DNA.
DR RefSeq; NP_457740.1; NC_003198.1.
DR RefSeq; WP_000510909.1; NZ_WSUR01000038.1.
DR AlphaFoldDB; Q8Z3D8; -.
DR STRING; 220341.16504426; -.
DR EnsemblBacteria; AAO70814; AAO70814; t3279.
DR KEGG; stt:t3279; -.
DR KEGG; sty:STY3545; -.
DR PATRIC; fig|220341.7.peg.3608; -.
DR eggNOG; COG1289; Bacteria.
DR HOGENOM; CLU_027647_0_0_6; -.
DR OMA; MITQACE; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046942; P:carboxylic acid transport; IEA:InterPro.
DR HAMAP; MF_01545; AaeB; 1.
DR InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR InterPro; IPR023706; PHBA_efflux_pump_AaeB.
DR PANTHER; PTHR30509:SF10; PTHR30509:SF10; 1.
DR Pfam; PF04632; FUSC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..655
FT /note="p-hydroxybenzoic acid efflux pump subunit AaeB"
FT /id="PRO_0000210083"
FT TOPO_DOM 1..12
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 34..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 59..68
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 90..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 114..120
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 142..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 173..369
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 391..406
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 428..430
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 452..459
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 481
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 482..502
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TOPO_DOM 503..655
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 655 AA; 73688 MW; 4D6F97B247957A2A CRC64;
MGIFSIANQH IRFAVKLACA IVLALFIGFH FQLETPRWAV LTAAIVAAGP AFAAGGEPYS
GAIRYRGMLR IIGTFIGCIA ALIIIISMIR APLLMILVCC VWAGFCTWIS SLVRIENSYA
WGLSGYTALI IVITIQTEPL LTPQFALERC SEIVIGIGCA ILADLLFSPR SIKQEVDREL
DCLLVAQYQL MQLCIKHGDS EEVDNAWGDL VRRTAALEGM RSNLNMESSR WVRANRRLKA
LNTLSLTLIT QSCETYLIQN TRPELITDTF RELFETPVET VQDVHRQLKR MRRVIVWTGE
RETPVTLYSW VGAATRYLLL KRGVISNTKI SATEEEILQG EPVVKVESAE RHHAMVNFWR
TTLSCILGTL FWLWTGWTSG NGAMVMIAVV TSLAMRLPNP RMVCIDFIYG TLAALPLGLL
YFLVIIPNTQ QSMLLLCLSL AVLGFFIGIE VQKRRLGSMG ALASTINIIV LDNPMTFHFI
QFLDSALGQI VGCMLAFIVI LLVRDKSKDR TGRVLLNQFV SAAVSAMTTN VVRRKENRLP
ALYQQLFLLM NKFPGDLPKF RLALTMIIAH QRLRDAPIPV NEDLSVFHRQ LRRTADHVIS
AGSDDKRRRY FGQLLDELDI YQEKLRIWEA PPQVTEPVKR LTGMLHKYQN ALTDS
