RAG1_KLULA
ID RAG1_KLULA Reviewed; 567 AA.
AC P18631;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Low-affinity glucose transporter;
DE AltName: Full=Hexose transporter 1;
GN Name=RAG1; Synonyms=KHT1; OrderedLocusNames=KLLA0D13310g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX PubMed=2402460; DOI=10.1093/nar/18.17.5294;
RA Goffrini P., Wesolowski-Louvel M., Ferrero I., Fukuhara H.;
RT "RAG1 gene of the yeast Kluyveromyces lactis codes for a sugar
RT transporter.";
RL Nucleic Acids Res. 18:5294-5294(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [3]
RP CHARACTERIZATION.
RX PubMed=1603078; DOI=10.1007/bf00587565;
RA Wesolowski-Louvel M., Goffrini P., Ferrero I., Fukuhara H.;
RT "Glucose transport in the yeast Kluyveromyces lactis. I. Properties of an
RT inducible low-affinity glucose transporter gene.";
RL Mol. Gen. Genet. 233:89-96(1992).
CC -!- FUNCTION: Low-affinity glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X53752; CAA37781.1; -; Genomic_DNA.
DR EMBL; CR382124; CAH00752.1; -; Genomic_DNA.
DR PIR; S11295; S11295.
DR RefSeq; XP_453656.1; XM_453656.1.
DR AlphaFoldDB; P18631; -.
DR SMR; P18631; -.
DR STRING; 28985.XP_453656.1; -.
DR EnsemblFungi; CAH00752; CAH00752; KLLA0_D13310g.
DR GeneID; 2892737; -.
DR KEGG; kla:KLLA0_D13310g; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_1_1; -.
DR InParanoid; P18631; -.
DR OMA; FWNIIFC; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005353; F:fructose transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0015578; F:mannose transmembrane transporter activity; IEA:EnsemblFungi.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..567
FT /note="Low-affinity glucose transporter"
FT /id="PRO_0000050419"
FT TOPO_DOM 18..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..199
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..234
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..354
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 355..358
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 380..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..466
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..493
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 494..514
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 515..567
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 567 AA; 63124 MW; 89CB737202B117C2 CRC64;
MSNQMTDSTS AGSGTEHSVD TNTALKAGSP NDLKVSHEED LNDLEKTAEE TLQQKPAKEY
IFVSLCCVMV AFGGFVFGWD TGTISGFVNQ TDFLRRFGQE KADGSHYLSN VRTGLIVSIF
NIGCAVGGIV LSNIGDRWGR RIGLITVIII YVIGIIIQIA SVDKWYQYFI GRIISGLGVG
GITVLSPMLI SETAPKHLRG TLVSCYQLMI TFGIFLGYCT NYGTKNYSNS VQWRVPLGLC
FAWAIFMVLG MMFVPESARF LVETDQIEEA RKSLAKTNKV SIDDPVVKYE LLKIQSSIEL
EKAAGNASWG ELITGKPSMF RRTLMGIMIQ SLQQLTGDNY FFYYGTTIFQ SVGMDDSFET
SIVLGIVNFA STFFALYTVD HFGRRNCLLY GCVGMVACYV VYASVGVTRL WPDGPDHPDI
SSKGAGNCMI VFACFYIFCF ATTWAPIAYV VISESYPLRV KGKAMAIASA SNWIWGFLIG
FFTPFITSAI HFYYGYVFMG CMVFAFFYVY FFVPETKGLT LEEVNEMYSE GVLPWKSSSW
VPSSRRGAEY DVDALQHDDK PWYKAML
