RAG3E_ARATH
ID RAG3E_ARATH Reviewed; 206 AA.
AC Q9XI98;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Ras-related protein RABG3e;
DE Short=AtRABG3e;
DE AltName: Full=Ras-related protein Rab74;
DE Short=AtRab74;
GN Name=RABG3E; Synonyms=RAB74; OrderedLocusNames=At1g49300;
GN ORFNames=F13F21.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ueda T., Wada Y., Nakano A.;
RT "Rab7 homologs in Arabidopsis thaliana.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644670; DOI=10.1104/pp.013052;
RA Vernoud V., Horton A.C., Yang Z., Nielsen E.;
RT "Analysis of the small GTPase gene superfamily of Arabidopsis.";
RL Plant Physiol. 131:1191-1208(2003).
RN [7]
RP FUNCTION, AND INDUCTION.
RX PubMed=14657401; DOI=10.1104/pp.103.025379;
RA Mazel A., Leshem Y., Tiwari B.S., Levine A.;
RT "Induction of salt and osmotic stress tolerance by overexpression of an
RT intracellular vesicle trafficking protein AtRab7 (AtRabG3e).";
RL Plant Physiol. 134:118-128(2004).
CC -!- FUNCTION: Intracellular vesicle trafficking and protein transport. May
CC play a role in adaptation to stress by recylcing macromolecules in
CC specific cellular compartments. {ECO:0000269|PubMed:14657401}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- INDUCTION: By hydrogen peroxide and infection with an incompatible race
CC of P.syringae and B.cinerea. {ECO:0000269|PubMed:14657401}.
CC -!- MISCELLANEOUS: Plants overexpressing RABG3E exhibit accelerated
CC endocytosis, increased tolerance to salt and osmotic stresses and
CC reduced accumulation of reactive oxygen species during salt stress.
CC {ECO:0000305|PubMed:14657401}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AB071849; BAB68374.1; -; mRNA.
DR EMBL; AC007504; AAD43167.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32414.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32415.1; -; Genomic_DNA.
DR EMBL; BT004594; AAO42840.1; -; mRNA.
DR EMBL; AK227548; BAE99544.1; -; mRNA.
DR PIR; C96529; C96529.
DR RefSeq; NP_001031161.1; NM_001036084.2.
DR RefSeq; NP_175355.1; NM_103820.4.
DR AlphaFoldDB; Q9XI98; -.
DR SMR; Q9XI98; -.
DR BioGRID; 26578; 1.
DR IntAct; Q9XI98; 1.
DR STRING; 3702.AT1G49300.2; -.
DR PaxDb; Q9XI98; -.
DR PRIDE; Q9XI98; -.
DR ProteomicsDB; 235073; -.
DR EnsemblPlants; AT1G49300.1; AT1G49300.1; AT1G49300.
DR EnsemblPlants; AT1G49300.2; AT1G49300.2; AT1G49300.
DR GeneID; 841353; -.
DR Gramene; AT1G49300.1; AT1G49300.1; AT1G49300.
DR Gramene; AT1G49300.2; AT1G49300.2; AT1G49300.
DR KEGG; ath:AT1G49300; -.
DR Araport; AT1G49300; -.
DR TAIR; locus:2010257; AT1G49300.
DR eggNOG; KOG0394; Eukaryota.
DR HOGENOM; CLU_041217_10_6_1; -.
DR InParanoid; Q9XI98; -.
DR OMA; EINAIRW; -.
DR OrthoDB; 1172019at2759; -.
DR PhylomeDB; Q9XI98; -.
DR PRO; PR:Q9XI98; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XI98; baseline and differential.
DR Genevisible; Q9XI98; AT.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IMP:TAIR.
DR GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..206
FT /note="Ras-related protein RABG3e"
FT /id="PRO_0000407365"
FT MOTIF 37..45
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 158..159
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 206
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 204
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 206
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 206 AA; 22980 MW; EA3ED061CB9DE16B CRC64;
MPSRRRTLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV QFEDRLFTLQ
IWDTAGQERF QSLGVAFYRG ADCCVLVYDV NSAKSFEDLN NWREEFLIQA SPSDPENFPF
VVIGNKIDVD GGSSRVVSEK KARAWCASKG NIPYYETSAK VGTNVEDAFL CITTNAMKSG
EEEEMYLPDT IDVGTSNPQR STGCEC
