RAI2_HUMAN
ID RAI2_HUMAN Reviewed; 530 AA.
AC Q9Y5P3; B1B1K2; B4DQM9; E7EMN4; Q8N6X7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Retinoic acid-induced protein 2;
GN Name=RAI2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-252.
RX PubMed=10049581; DOI=10.1006/geno.1998.5667;
RA Walpole S.M., Hiriyana K.T., Nicolaou A., Bingham E.L., Durham J.,
RA Vaudin M., Ross M.T., Yates J.R.W., Sieving P.A., Trump D.;
RT "Identification and characterization of the human homologue (RAI2) of a
RT mouse retinoic acid-induced gene in Xp22.";
RL Genomics 55:275-283(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT VAL-252.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS VAL-252
RP AND PRO-342.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9Y5P3; Q13363: CTBP1; NbExp=3; IntAct=EBI-746228, EBI-908846;
CC Q9Y5P3; P56545: CTBP2; NbExp=4; IntAct=EBI-746228, EBI-741533;
CC Q9Y5P3; P56545-3: CTBP2; NbExp=3; IntAct=EBI-746228, EBI-10171902;
CC Q9Y5P3; Q01658: DR1; NbExp=3; IntAct=EBI-746228, EBI-750300;
CC Q9Y5P3; Q14192: FHL2; NbExp=7; IntAct=EBI-746228, EBI-701903;
CC Q9Y5P3; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-746228, EBI-1054873;
CC Q9Y5P3; P04792: HSPB1; NbExp=3; IntAct=EBI-746228, EBI-352682;
CC Q9Y5P3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-746228, EBI-10975473;
CC Q9Y5P3; P07196: NEFL; NbExp=3; IntAct=EBI-746228, EBI-475646;
CC Q9Y5P3; P60891: PRPS1; NbExp=3; IntAct=EBI-746228, EBI-749195;
CC Q9Y5P3; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-746228, EBI-396669;
CC Q9Y5P3; Q96EQ0: SGTB; NbExp=5; IntAct=EBI-746228, EBI-744081;
CC Q9Y5P3; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-746228, EBI-741480;
CC Q9Y5P3; Q9NRR5: UBQLN4; NbExp=3; IntAct=EBI-746228, EBI-711226;
CC Q9Y5P3; O76024: WFS1; NbExp=3; IntAct=EBI-746228, EBI-720609;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y5P3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y5P3-2; Sequence=VSP_047524;
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DR EMBL; AF136587; AAD33688.1; -; Genomic_DNA.
DR EMBL; AK298873; BAG60991.1; -; mRNA.
DR EMBL; Z93242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027937; AAH27937.1; -; mRNA.
DR CCDS; CCDS14183.1; -. [Q9Y5P3-1]
DR CCDS; CCDS55374.1; -. [Q9Y5P3-2]
DR RefSeq; NP_001166203.1; NM_001172732.1. [Q9Y5P3-2]
DR RefSeq; NP_001166210.1; NM_001172739.1. [Q9Y5P3-1]
DR RefSeq; NP_001166214.1; NM_001172743.1. [Q9Y5P3-1]
DR RefSeq; NP_068557.3; NM_021785.4. [Q9Y5P3-1]
DR RefSeq; XP_006724522.1; XM_006724459.2. [Q9Y5P3-1]
DR RefSeq; XP_006724523.1; XM_006724460.1. [Q9Y5P3-1]
DR RefSeq; XP_011543741.1; XM_011545439.2. [Q9Y5P3-1]
DR RefSeq; XP_011543742.1; XM_011545440.2. [Q9Y5P3-1]
DR RefSeq; XP_011543743.1; XM_011545441.2. [Q9Y5P3-1]
DR AlphaFoldDB; Q9Y5P3; -.
DR BioGRID; 115965; 21.
DR IntAct; Q9Y5P3; 26.
DR MINT; Q9Y5P3; -.
DR STRING; 9606.ENSP00000444210; -.
DR iPTMnet; Q9Y5P3; -.
DR PhosphoSitePlus; Q9Y5P3; -.
DR BioMuta; RAI2; -.
DR DMDM; 205371817; -.
DR MassIVE; Q9Y5P3; -.
DR PaxDb; Q9Y5P3; -.
DR PeptideAtlas; Q9Y5P3; -.
DR PRIDE; Q9Y5P3; -.
DR ProteomicsDB; 16981; -.
DR ProteomicsDB; 86462; -. [Q9Y5P3-1]
DR Antibodypedia; 35327; 41 antibodies from 19 providers.
DR DNASU; 10742; -.
DR Ensembl; ENST00000331511.5; ENSP00000333456.1; ENSG00000131831.18. [Q9Y5P3-1]
DR Ensembl; ENST00000360011.5; ENSP00000353106.1; ENSG00000131831.18. [Q9Y5P3-1]
DR Ensembl; ENST00000415486.7; ENSP00000392578.2; ENSG00000131831.18. [Q9Y5P3-2]
DR Ensembl; ENST00000451717.6; ENSP00000401323.1; ENSG00000131831.18. [Q9Y5P3-1]
DR Ensembl; ENST00000545871.1; ENSP00000444210.1; ENSG00000131831.18. [Q9Y5P3-1]
DR GeneID; 10742; -.
DR KEGG; hsa:10742; -.
DR MANE-Select; ENST00000451717.6; ENSP00000401323.1; NM_021785.6; NP_068557.4.
DR UCSC; uc004cyf.4; human. [Q9Y5P3-1]
DR CTD; 10742; -.
DR DisGeNET; 10742; -.
DR GeneCards; RAI2; -.
DR HGNC; HGNC:9835; RAI2.
DR HPA; ENSG00000131831; Low tissue specificity.
DR MIM; 300217; gene.
DR neXtProt; NX_Q9Y5P3; -.
DR OpenTargets; ENSG00000131831; -.
DR PharmGKB; PA34193; -.
DR VEuPathDB; HostDB:ENSG00000131831; -.
DR eggNOG; ENOG502RCMZ; Eukaryota.
DR GeneTree; ENSGT00940000154164; -.
DR HOGENOM; CLU_044853_0_0_1; -.
DR InParanoid; Q9Y5P3; -.
DR OMA; EFSRQHK; -.
DR OrthoDB; 956789at2759; -.
DR PhylomeDB; Q9Y5P3; -.
DR TreeFam; TF331261; -.
DR PathwayCommons; Q9Y5P3; -.
DR SignaLink; Q9Y5P3; -.
DR BioGRID-ORCS; 10742; 7 hits in 698 CRISPR screens.
DR ChiTaRS; RAI2; human.
DR GeneWiki; RAI2; -.
DR GenomeRNAi; 10742; -.
DR Pharos; Q9Y5P3; Tdark.
DR PRO; PR:Q9Y5P3; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9Y5P3; protein.
DR Bgee; ENSG00000131831; Expressed in left uterine tube and 182 other tissues.
DR ExpressionAtlas; Q9Y5P3; baseline and differential.
DR Genevisible; Q9Y5P3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; NAS:UniProtKB.
DR InterPro; IPR026092; RAI2/SOBP.
DR PANTHER; PTHR23186; PTHR23186; 1.
DR Pfam; PF15279; SOBP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..530
FT /note="Retinoic acid-induced protein 2"
FT /id="PRO_0000097161"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 46..95
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047524"
FT VARIANT 252
FT /note="M -> V (in dbSNP:rs6527818)"
FT /evidence="ECO:0000269|PubMed:10049581,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_046100"
FT VARIANT 342
FT /note="A -> P (in dbSNP:rs17855524)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_046101"
SQ SEQUENCE 530 AA; 57180 MW; F5BEE12367961C9A CRC64;
MDDLQSQNLS MDMTDSPPAL ANNRLENGMA QLITTEAWNI NSTDLVKKAL VTVPAPSILN
PPAESQSGMA LKVAATVLQP LCLGESPVVM PIHMQVEGSS APELNPNGNA TYVMTTQGPV
QLPVVLEQHV FQHLNSPLVL PQEAPCSSST IHNNLFQGAE DPEAQPQLLD LRIPSQPQEP
TLPFEAVLQN LFPSQGTLGP PPCQPPPGYA PVPPQPFSSP LSPLVPPATL LVPYPVIVPL
PVPVPIPIPI PMPQSSESKF SSSFPKPPSS FGLHPFKGTQ TPLEKDELKP FDILQPKEYF
QLSRHTVIKM GSENEALDLS MKSVPWLKAG EVSPPIFQED AALDLSVAAH RKSEPPPETL
YDSGASVDSS GHTVMEKLPS GMEISFAPAT SHEAPAMMDS HISSSDAATE MLSQPNHPSG
EVKAENNIEM VGESQAAKVI VSVEDAVPTI FCGKIKGLSG VSTKNFSFKR EDSVLQGYDI
NSQGEESMGN AEPLRKPIKN RSIKLKKVNS QEIHMLPIKK QRLATFFPRK
