ID   RALB_TODPA              Reviewed;         343 AA.
AC   P49193;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Retinal-binding protein;
DE            Short=RALBP;
OS   Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae; Todarodes.
OX   NCBI_TaxID=6637;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND ACETYLATION AT
RP   SER-2.
RC   TISSUE=Eye;
RX   PubMed=8106428; DOI=10.1016/s0021-9258(17)41936-3;
RA   Ozaki K., Terakita A., Ozaki M., Hara R., Hara T., Hara-Nishimura I.,
RA   Mori H., Nishimura M.;
RT   "Molecular characterization and functional expression of squid retinal-
RT   binding protein. A novel species of hydrophobic ligand-binding protein.";
RL   J. Biol. Chem. 269:3838-3845(1994).
CC   -!- FUNCTION: Shuttles 11-cis- and all-trans-retinals between rhodopsin and
CC       retinochrome and regenerates the photoproducts of both pigments. Also
CC       binds weakly to retinol.
CC   -!- TISSUE SPECIFICITY: Outer and inner segments of photoreceptor cells.
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DR   EMBL; S68871; AAB29891.1; -; mRNA.
DR   PIR; A53057; A53057.
DR   AlphaFoldDB; P49193; -.
DR   SMR; P49193; -.
DR   iPTMnet; P49193; -.
DR   BioCyc; MetaCyc:MON-17360; -.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF13897; GOLD_2; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Sensory transduction; Transport;
KW   Vision.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..343
FT                   /note="Retinal-binding protein"
FT                   /id="PRO_0000210762"
FT   DOMAIN          18..191
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   DOMAIN          206..316
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:8106428"
SQ   SEQUENCE   343 AA;  39201 MW;  E1DE7051B01B2D75 CRC64;
     MSLREQMGAD TLIAEYTPPD VIQKFMTGGD VGHDKDGSVL RIEPWGYLDM KGIMYSCKKS
     DLEKSKLLQC EKHLKDLEAQ SEKVGKPCTG LTVVFDMENV GSKHMWKPGL DMYLYLVQVL
     EDNYPEMMKR LFVINAPTLF PVLYKLVKPL LSEDMKNKIF VLGGDYKDTL LEYIDAEELP
     AYLGGTKSEG DEKCSELICH GGEVPKEFYL ENTDDFETME TITVGSGDKI YVEYEIENEN
     TYIKWEYKTE EHDIGFGLFR KNGDEWEEVV PIERTDCSIM TLDGSHKCKD PGTYALCFDN
     SFSMMTSKNV RYTAEVMDPE VDSEDINKMI KDSTWDELSA QIS