RALYL_HUMAN
ID RALYL_HUMAN Reviewed; 291 AA.
AC Q86SE5; B3KTH2; G3V129; Q6ZW87; Q8N1C2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=RNA-binding Raly-like protein;
DE Short=hRALYL;
DE AltName: Full=Heterogeneous nuclear ribonucleoprotein C-like 3;
DE Short=hnRNP core protein C-like 3;
GN Name=RALYL; Synonyms=HNRPCL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12688537; DOI=10.1023/a:1022295311177;
RA Ji C.N., Chen J.Z., Xie Y., Wang S., Qian J., Zhao E., Jin W., Wu X.Z.,
RA Xu W.X., Ying K., Mao Y.M.;
RT "A novel cDNA encodes a putative hRALY-like protein, hRALYL.";
RL Mol. Biol. Rep. 30:61-67(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Subthalamic nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q86SE5; Q8WTP8: AEN; NbExp=3; IntAct=EBI-741520, EBI-8637627;
CC Q86SE5; Q13895: BYSL; NbExp=3; IntAct=EBI-741520, EBI-358049;
CC Q86SE5; P07910: HNRNPC; NbExp=7; IntAct=EBI-741520, EBI-357966;
CC Q86SE5; Q86SE5: RALYL; NbExp=3; IntAct=EBI-741520, EBI-741520;
CC Q86SE5; Q96IZ5: RBM41; NbExp=4; IntAct=EBI-741520, EBI-740773;
CC Q86SE5; Q9NVV9: THAP1; NbExp=4; IntAct=EBI-741520, EBI-741515;
CC Q86SE5-3; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-11526555, EBI-1383687;
CC Q86SE5-3; P07910: HNRNPC; NbExp=3; IntAct=EBI-11526555, EBI-357966;
CC Q86SE5-3; O60812: HNRNPCL1; NbExp=3; IntAct=EBI-11526555, EBI-1046507;
CC Q86SE5-3; B2RXH8: HNRNPCL2; NbExp=3; IntAct=EBI-11526555, EBI-9512317;
CC Q86SE5-3; Q53GL6: RALY; NbExp=3; IntAct=EBI-11526555, EBI-9512693;
CC Q86SE5-3; Q86SE5-3: RALYL; NbExp=3; IntAct=EBI-11526555, EBI-11526555;
CC Q86SE5-3; Q9NVV9: THAP1; NbExp=6; IntAct=EBI-11526555, EBI-741515;
CC Q86SE5-3; Q6B0B8: TIGD3; NbExp=3; IntAct=EBI-11526555, EBI-12140557;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86SE5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86SE5-2; Sequence=VSP_027725, VSP_027726;
CC Name=3;
CC IsoId=Q86SE5-3; Sequence=VSP_054067;
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in brain.
CC {ECO:0000269|PubMed:12688537}.
CC -!- SIMILARITY: Belongs to the RRM HNRPC family. RALY subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31090.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF495529; AAO85516.1; -; mRNA.
DR EMBL; AF495530; AAO85517.1; -; mRNA.
DR EMBL; AK095560; BAG53084.1; -; mRNA.
DR EMBL; AK123437; BAC85617.1; -; mRNA.
DR EMBL; AC009901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC027043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC103816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471068; EAW87118.1; -; Genomic_DNA.
DR EMBL; BC031090; AAH31090.1; ALT_INIT; mRNA.
DR CCDS; CCDS55252.1; -. [Q86SE5-3]
DR CCDS; CCDS55253.1; -. [Q86SE5-1]
DR CCDS; CCDS75761.1; -. [Q86SE5-2]
DR RefSeq; NP_001093861.1; NM_001100391.1. [Q86SE5-3]
DR RefSeq; NP_001093862.1; NM_001100392.1. [Q86SE5-1]
DR RefSeq; NP_001093863.1; NM_001100393.1. [Q86SE5-1]
DR RefSeq; NP_001274173.1; NM_001287244.1. [Q86SE5-2]
DR RefSeq; NP_776247.3; NM_173848.5. [Q86SE5-1]
DR RefSeq; XP_016868548.1; XM_017013059.1.
DR RefSeq; XP_016868549.1; XM_017013060.1.
DR RefSeq; XP_016868550.1; XM_017013061.1.
DR RefSeq; XP_016868551.1; XM_017013062.1.
DR RefSeq; XP_016868552.1; XM_017013063.1.
DR RefSeq; XP_016868553.1; XM_017013064.1.
DR RefSeq; XP_016868554.1; XM_017013065.1.
DR AlphaFoldDB; Q86SE5; -.
DR SMR; Q86SE5; -.
DR BioGRID; 126498; 75.
DR IntAct; Q86SE5; 45.
DR MINT; Q86SE5; -.
DR STRING; 9606.ENSP00000430128; -.
DR GlyGen; Q86SE5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86SE5; -.
DR PhosphoSitePlus; Q86SE5; -.
DR BioMuta; RALYL; -.
DR DMDM; 158564044; -.
DR jPOST; Q86SE5; -.
DR MassIVE; Q86SE5; -.
DR MaxQB; Q86SE5; -.
DR PaxDb; Q86SE5; -.
DR PeptideAtlas; Q86SE5; -.
DR PRIDE; Q86SE5; -.
DR ProteomicsDB; 32239; -.
DR ProteomicsDB; 69574; -. [Q86SE5-1]
DR ProteomicsDB; 69575; -. [Q86SE5-2]
DR Antibodypedia; 25367; 141 antibodies from 22 providers.
DR DNASU; 138046; -.
DR Ensembl; ENST00000517638.5; ENSP00000430128.1; ENSG00000184672.12. [Q86SE5-3]
DR Ensembl; ENST00000521268.6; ENSP00000430367.1; ENSG00000184672.12. [Q86SE5-1]
DR Ensembl; ENST00000521695.5; ENSP00000428667.1; ENSG00000184672.12. [Q86SE5-1]
DR Ensembl; ENST00000522455.5; ENSP00000430394.1; ENSG00000184672.12. [Q86SE5-1]
DR Ensembl; ENST00000523850.5; ENSP00000428807.1; ENSG00000184672.12. [Q86SE5-2]
DR GeneID; 138046; -.
DR KEGG; hsa:138046; -.
DR MANE-Select; ENST00000521268.6; ENSP00000430367.1; NM_173848.7; NP_776247.3.
DR UCSC; uc003ycq.5; human. [Q86SE5-1]
DR CTD; 138046; -.
DR DisGeNET; 138046; -.
DR GeneCards; RALYL; -.
DR HGNC; HGNC:27036; RALYL.
DR HPA; ENSG00000184672; Group enriched (adrenal gland, brain, kidney).
DR MIM; 614648; gene.
DR neXtProt; NX_Q86SE5; -.
DR OpenTargets; ENSG00000184672; -.
DR PharmGKB; PA162400636; -.
DR VEuPathDB; HostDB:ENSG00000184672; -.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000156907; -.
DR HOGENOM; CLU_079090_2_0_1; -.
DR InParanoid; Q86SE5; -.
DR OrthoDB; 1333811at2759; -.
DR PhylomeDB; Q86SE5; -.
DR TreeFam; TF330974; -.
DR PathwayCommons; Q86SE5; -.
DR SignaLink; Q86SE5; -.
DR BioGRID-ORCS; 138046; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; RALYL; human.
DR GeneWiki; RALYL; -.
DR GenomeRNAi; 138046; -.
DR Pharos; Q86SE5; Tbio.
DR PRO; PR:Q86SE5; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q86SE5; protein.
DR Bgee; ENSG00000184672; Expressed in endothelial cell and 117 other tissues.
DR ExpressionAtlas; Q86SE5; baseline and differential.
DR Genevisible; Q86SE5; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR CDD; cd12605; RRM_RALYL; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR017347; hnRNP_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034504; RALYL_RRM.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037992; hnRNP-C_Raly; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome; RNA-binding.
FT CHAIN 1..291
FT /note="RNA-binding Raly-like protein"
FT /id="PRO_0000299525"
FT DOMAIN 21..92
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 171..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 190..249
FT /evidence="ECO:0000255"
FT COMPBIAS 177..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..282
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..73
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027725"
FT VAR_SEQ 1
FT /note="M -> MSKRRRLKQGEPIM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054067"
FT VAR_SEQ 74..86
FT /note="GENARVIAGQPLD -> MTMYKSKRRHQRY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027726"
FT CONFLICT 142
FT /note="Y -> F (in Ref. 1; AAO85516/AAO85517)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 291 AA; 32331 MW; A07D1D72029B3DC4 CRC64;
MTGKTQTSNV TNKNDPKSIN SRVFIGNLNT AIVKKVDIEA IFSKYGKIVG CSVHKGYAFV
QYMSERHARA AVAGENARVI AGQPLDINMA GEPKPYRPKP GNKRPLSALY RLESKEPFLS
VGGYVFDYDY YRDDFYNRLF DYHGRVPPPP RAVIPLKRPR VAVTTTRRGK GVFSMKGGSR
STASGSTGSK LKSDELQTIK KELTQIKTKI DSLLGRLEKI EKQQKAEAEA QKKQLEESLV
LIQEECVSEI ADHSTEEPAE GGPDADGEEM TDGIEEDFDE DGGHELFLQI K
