RALYL_MOUSE
ID RALYL_MOUSE Reviewed; 293 AA.
AC Q8BTF8; Q8BTF9; Q8BTG1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=RNA-binding Raly-like protein;
GN Name=Ralyl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, Medulla oblongata, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BTF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BTF8-2; Sequence=VSP_027727, VSP_027728;
CC -!- SIMILARITY: Belongs to the RRM HNRPC family. RALY subfamily.
CC {ECO:0000305}.
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DR EMBL; AK032086; BAC27689.1; -; mRNA.
DR EMBL; AK038465; BAC30009.1; -; mRNA.
DR EMBL; AK079659; BAC37718.1; -; mRNA.
DR EMBL; BC052358; AAH52358.1; -; mRNA.
DR CCDS; CCDS50863.1; -. [Q8BTF8-2]
DR CCDS; CCDS84609.1; -. [Q8BTF8-1]
DR RefSeq; NP_001156800.1; NM_001163328.1. [Q8BTF8-1]
DR RefSeq; NP_001156801.1; NM_001163329.1. [Q8BTF8-2]
DR RefSeq; NP_848746.1; NM_178631.4. [Q8BTF8-1]
DR RefSeq; XP_011246452.1; XM_011248150.2. [Q8BTF8-1]
DR RefSeq; XP_017175290.1; XM_017319801.1.
DR AlphaFoldDB; Q8BTF8; -.
DR SMR; Q8BTF8; -.
DR BioGRID; 218384; 1.
DR STRING; 10090.ENSMUSP00000104009; -.
DR iPTMnet; Q8BTF8; -.
DR PhosphoSitePlus; Q8BTF8; -.
DR MaxQB; Q8BTF8; -.
DR PaxDb; Q8BTF8; -.
DR PeptideAtlas; Q8BTF8; -.
DR PRIDE; Q8BTF8; -.
DR ProteomicsDB; 300392; -. [Q8BTF8-1]
DR ProteomicsDB; 300393; -. [Q8BTF8-2]
DR Antibodypedia; 25367; 141 antibodies from 22 providers.
DR DNASU; 76897; -.
DR Ensembl; ENSMUST00000108372; ENSMUSP00000104009; ENSMUSG00000039717. [Q8BTF8-2]
DR Ensembl; ENSMUST00000193117; ENSMUSP00000148795; ENSMUSG00000039717. [Q8BTF8-1]
DR GeneID; 76897; -.
DR KEGG; mmu:76897; -.
DR UCSC; uc008oqb.2; mouse. [Q8BTF8-1]
DR UCSC; uc008oqf.2; mouse. [Q8BTF8-2]
DR CTD; 138046; -.
DR MGI; MGI:1924147; Ralyl.
DR VEuPathDB; HostDB:ENSMUSG00000039717; -.
DR eggNOG; KOG0118; Eukaryota.
DR GeneTree; ENSGT00940000156907; -.
DR HOGENOM; CLU_079090_2_0_1; -.
DR InParanoid; Q8BTF8; -.
DR OMA; DEDCSNE; -.
DR OrthoDB; 1333811at2759; -.
DR PhylomeDB; Q8BTF8; -.
DR TreeFam; TF330974; -.
DR BioGRID-ORCS; 76897; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ralyl; mouse.
DR PRO; PR:Q8BTF8; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BTF8; protein.
DR Bgee; ENSMUSG00000039717; Expressed in mammillary body and 104 other tissues.
DR ExpressionAtlas; Q8BTF8; baseline and differential.
DR Genevisible; Q8BTF8; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd12605; RRM_RALYL; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR017347; hnRNP_C.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034504; RALYL_RRM.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037992; hnRNP-C_Raly; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; RNA-binding.
FT CHAIN 1..293
FT /note="RNA-binding Raly-like protein"
FT /id="PRO_0000299526"
FT DOMAIN 21..92
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 171..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 192..255
FT /evidence="ECO:0000255"
FT COMPBIAS 179..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..73
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_027727"
FT VAR_SEQ 74..86
FT /note="GENARVIAGQPLD -> MTMYRSKRRHQRY (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_027728"
FT CONFLICT 211
FT /note="K -> R (in Ref. 1; BAC27689)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 32452 MW; A7FC5C4B1F3A80DF CRC64;
MTGKTQTSNI TNKNDPKSIN SRVFIGNLNT AIVKKVDIEA IFSKYGKIVG CSVHKGYAFV
QYMSERHARA AVAGENARVI AGQPLDINMA GEPKPYRPKP GSKRPLSALY RLESKEPFLS
VGGYVFDYDY YRDDFYNRLF DYHGRVPPPP RAVIPLKRPR VAVTTTRRGK GVFSMKGGSR
STVGGSSSSG SKLKSDELQT IKKELTQIKT KIDSLLGRLE KIEKQQKAEA EAQKKQLEES
IELIQDECVS ENADHSTEEP AEGGQEADGG EMTDGVEEDF DEDGGHELFL QIK
