ID   RAL_BPP22               Reviewed;          64 AA.
AC   P14113; A8CGB6; Q77D62; Q7PCF5;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Restriction inhibitor protein ral;
DE   AltName: Full=Antirestriction protein;
GN   Name=ral;
OS   Salmonella phage P22 (Bacteriophage P22).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Podoviridae; Lederbergvirus.
OX   NCBI_TaxID=10754;
OH   NCBI_TaxID=90371; Salmonella typhimurium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=2738922; DOI=10.1016/0022-2836(89)90437-3;
RA   Semerjian A.V., Malloy D.C., Poteete A.R.;
RT   "Genetic structure of the bacteriophage P22 PL operon.";
RL   J. Mol. Biol. 207:1-13(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11053393; DOI=10.1128/jb.182.22.6472-6481.2000;
RA   Vander Byl C.S., Kropinski A.M.B.;
RT   "Sequence of the genome of Salmonella bacteriophage P22.";
RL   J. Bacteriol. 182:6472-6481(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12562822; DOI=10.1128/jb.185.4.1475-1477.2003;
RA   Pedulla M.L., Ford M.E., Karthikeyan T., Houtz J.M., Hendrix R.W.,
RA   Hatfull G.F., Poteete A.R., Gilcrease E.B., Winn-Stapley D.A.,
RA   Casjens S.R.;
RT   "Corrected sequence of the bacteriophage P22 genome.";
RL   J. Bacteriol. 185:1475-1477(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19585-B1 {ECO:0000312|Proteomes:UP000002165}, and
RC   MSU {ECO:0000312|EMBL:BAF80758.1, ECO:0000312|Proteomes:UP000002165};
RX   PubMed=18621868; DOI=10.1128/aem.00352-08;
RA   Masago Y., Shibata T., Rose J.B.;
RT   "Bacteriophage P22 and Staphylococcus aureus attenuation on nonporous
RT   fomites as determined by plate assay and quantitative PCR.";
RL   Appl. Environ. Microbiol. 74:5838-5840(2008).
CC   -!- FUNCTION: Ral interferes with the cleavage of DNA by E.coli EcoK
CC       restriction-modification system, by modifying the activity of the host
CC       methylase (By similarity). This modulation allows incoming, unmodified
CC       phages to escape the host's restriction system (PubMed:2738922).
CC       {ECO:0000250|UniProtKB:P03703, ECO:0000269|PubMed:2738922}.
CC   -!- SIMILARITY: Belongs to the lambda phage ral family. {ECO:0000305}.
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DR   EMBL; X15637; CAA33647.1; -; Genomic_DNA.
DR   EMBL; AF217253; AAF75021.1; -; Genomic_DNA.
DR   EMBL; BK000583; DAA01018.1; -; Genomic_DNA.
DR   EMBL; AF527608; AAM81420.1; -; Genomic_DNA.
DR   EMBL; AB362338; BAF80758.1; -; Genomic_DNA.
DR   EMBL; AB426868; BAG12641.1; -; Genomic_DNA.
DR   PIR; S04245; QABP22.
DR   RefSeq; NP_059603.1; NC_002371.2.
DR   GeneID; 1262811; -.
DR   KEGG; vg:1262811; -.
DR   Proteomes; UP000001315; Genome.
DR   Proteomes; UP000001795; Genome.
DR   Proteomes; UP000001796; Genome.
DR   Proteomes; UP000002165; Genome.
DR   Proteomes; UP000007960; Genome.
DR   GO; GO:0099018; P:evasion by virus of host restriction-modification system; IEA:UniProtKB-KW.
DR   InterPro; IPR022759; Antirestriction_protein_Ral.
DR   Pfam; PF11058; Ral; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome;
KW   Restriction-modification system evasion by virus.
FT   CHAIN           1..64
FT                   /note="Restriction inhibitor protein ral"
FT                   /id="PRO_0000077697"
SQ   SEQUENCE   64 AA;  7407 MW;  404D18BD78D34884 CRC64;
     MTTTIDTNQW CSRFVKCKGC KLDAECMVKP EEMALVREDG KIVDKWAIRT TEMIARELEK
     LKAI