ID   RAL_LAMBD               Reviewed;          66 AA.
AC   P03703;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Restriction inhibitor protein ral;
DE   AltName: Full=Antirestriction protein;
GN   Name=ral;
OS   Escherichia phage lambda (Bacteriophage lambda).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Lambdavirus.
OX   NCBI_TaxID=10710;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6221115; DOI=10.1016/0022-2836(82)90546-0;
RA   Sanger F., Coulson A.R., Hong G.F., Hill D.F., Petersen G.B.;
RT   "Nucleotide sequence of bacteriophage lambda DNA.";
RL   J. Mol. Biol. 162:729-773(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6458018; DOI=10.1093/nar/9.18.4639;
RA   Ineichen K., Shepherd J.C.W., Bickle T.A.;
RT   "The DNA sequence of the phage lambda genome between PL and the gene bet.";
RL   Nucleic Acids Res. 9:4639-4653(1981).
RN   [3]
RP   FUNCTION.
RX   PubMed=3023633; DOI=10.1016/0022-2836(86)90071-9;
RA   Loenen W.A., Murray N.E.;
RT   "Modification enhancement by the restriction alleviation protein (Ral) of
RT   bacteriophage lambda.";
RL   J. Mol. Biol. 190:11-22(1986).
CC   -!- FUNCTION: Ral interferes with the cleavage of DNA by E.coli EcoK
CC       restriction-modification system, by modifying the activity of the host
CC       methylase. This modulation allows incoming, unmodified phages to escape
CC       the host's restriction system. {ECO:0000269|PubMed:3023633}.
CC   -!- SIMILARITY: Belongs to the lambda phage ral family. {ECO:0000305}.
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DR   EMBL; V00638; CAA23981.1; -; Genomic_DNA.
DR   EMBL; J02459; AAA96575.1; -; Genomic_DNA.
DR   PIR; G94164; QABPL.
DR   RefSeq; NP_040622.1; NC_001416.1.
DR   GeneID; 2703473; -.
DR   KEGG; vg:2703473; -.
DR   Proteomes; UP000001711; Genome.
DR   GO; GO:0099018; P:evasion by virus of host restriction-modification system; IEA:UniProtKB-KW.
DR   InterPro; IPR022759; Antirestriction_protein_Ral.
DR   Pfam; PF11058; Ral; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome;
KW   Restriction-modification system evasion by virus.
FT   CHAIN           1..66
FT                   /note="Restriction inhibitor protein ral"
FT                   /id="PRO_0000077699"
SQ   SEQUENCE   66 AA;  7604 MW;  A30D80D8CBA9AB02 CRC64;
     MTTTIDKNQW CGQFKRCNGC KLQSECMVKP EEMFPVMEDG KYVDKWAIRT TAMIARELGK
     QNNKAA