ID   RAMA_ENTCL              Reviewed;         113 AA.
AC   P55922;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Transcriptional activator RamA;
GN   Name=ramA;
OS   Enterobacter cloacae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX   NCBI_TaxID=550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2193928; DOI=10.1128/jb.172.7.4082-4089.1990;
RA   Komatsu T., Ohta M., Kido N., Arakawa Y., Ito H., Mizuno T., Kato N.;
RT   "Molecular characterization of an Enterobacter cloacae gene (romA) which
RT   pleiotropically inhibits the expression of Escherichia coli outer membrane
RT   proteins.";
RL   J. Bacteriol. 172:4082-4089(1990).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=7551053; DOI=10.1099/13500872-141-8-1909;
RA   George A.M., Hall R.M., Stokes H.W.;
RT   "Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers
RT   a multidrug resistance phenotype in Escherichia coli.";
RL   Microbiology 141:1909-1920(1995).
CC   -!- FUNCTION: Probable transcriptional activator.
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DR   AlphaFoldDB; P55922; -.
DR   SMR; P55922; -.
DR   STRING; 1399774.JDWH01000007_gene1694; -.
DR   eggNOG; COG2207; Bacteria.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..113
FT                   /note="Transcriptional activator RamA"
FT                   /id="PRO_0000194549"
FT   DOMAIN          9..107
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        26..47
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        74..97
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   113 AA;  13633 MW;  D9D57E77D64B9557 CRC64;
     MTISAQVIDT IVEWIDDNLH QPLRIEDIAR HAGYSKWHLQ RLFLQYKGES LGRYIRERKL
     LLAARDLRES DERVYEICLR YGFESQQTFT RIFTRTFHQP PGAYRKENHS RTH