ID   RAMA_KLEPN              Reviewed;         113 AA.
AC   Q48413;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Transcriptional activator RamA;
GN   Name=ramA;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ECL8;
RX   PubMed=7551053; DOI=10.1099/13500872-141-8-1909;
RA   George A.M., Hall R.M., Stokes H.W.;
RT   "Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA, confers
RT   a multidrug resistance phenotype in Escherichia coli.";
RL   Microbiology 141:1909-1920(1995).
CC   -!- FUNCTION: Probable transcriptional activator. Confers a multidrug
CC       resistance phenotype in E.coli.
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DR   EMBL; U19581; AAA85697.1; -; Genomic_DNA.
DR   PIR; T09627; T09627.
DR   RefSeq; WP_002893035.1; NZ_WYAM01000012.1.
DR   PDB; 7BEF; EM; 4.50 A; G=1-113.
DR   PDB; 7BEG; EM; 4.20 A; G=1-113.
DR   PDBsum; 7BEF; -.
DR   PDBsum; 7BEG; -.
DR   AlphaFoldDB; Q48413; -.
DR   SMR; Q48413; -.
DR   GeneID; 61331758; -.
DR   OMA; SCVAKQV; -.
DR   OrthoDB; 1748122at2; -.
DR   PHI-base; PHI:7475; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..113
FT                   /note="Transcriptional activator RamA"
FT                   /id="PRO_0000194550"
FT   DOMAIN          9..107
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        26..47
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        74..97
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   113 AA;  13495 MW;  46EE0D4154C66C9F CRC64;
     MTISAQVIDT IVEWIDDNLH QPLRIDDIAR HAGYSKWHLQ RLFLQYKGES LGRYIRERKL
     LLAARDLRDT DQRVYDICLK YGFDSQQTFT RVFTRTFNQP PGAYRKENHS RAH