RAMP1_MOUSE
ID RAMP1_MOUSE Reviewed; 148 AA.
AC Q9WTJ5;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Receptor activity-modifying protein 1;
DE Flags: Precursor;
GN Name=Ramp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=12147211; DOI=10.1054/npep.2002.0871;
RA Miyauchi K., Tadotsu N., Hayashi T., Ono Y., Tokoyoda K., Tsujikawa K.,
RA Yamamoto H.;
RT "Molecular cloning and characterization of mouse calcitonin gene-related
RT peptide receptor.";
RL Neuropeptides 36:22-33(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Derst C., Preisig-Mueller R., Gerhardus J., Daut J.;
RT "Cloning and sequencing of mouse CGRP/adrenomedullin receptor subunits.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10854696; DOI=10.1016/s0303-7207(00)00212-4;
RA Husmann K., Sexton P.M., Fischer J.A., Born W.;
RT "Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
RT sequence, expression and function.";
RL Mol. Cell. Endocrinol. 162:35-43(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=10777702; DOI=10.1006/bbrc.2000.2606;
RA Ono Y., Okano I., Kojima M., Okada K., Kangawa K.;
RT "Decreased gene expression of adrenomedullin receptor in mouse lungs during
RT sepsis.";
RL Biochem. Biophys. Res. Commun. 271:197-202(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC calcitonin-gene-related peptide (CGRP) together with CALCRL.
CC {ECO:0000269|PubMed:10854696, ECO:0000269|PubMed:12147211}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the thymus, skeletal
CC muscle, embryonic and adult brain, embryonic and adult lung, and colon.
CC {ECO:0000269|PubMed:10777702, ECO:0000269|PubMed:10854696,
CC ECO:0000269|PubMed:12147211}.
CC -!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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DR EMBL; AB019046; BAA76617.1; -; mRNA.
DR EMBL; AF146522; AAD35018.1; -; mRNA.
DR EMBL; AJ250489; CAB59511.1; -; mRNA.
DR EMBL; AF209904; AAF21036.1; -; mRNA.
DR EMBL; BC012644; AAH12644.1; -; mRNA.
DR CCDS; CCDS15158.1; -.
DR PIR; JC7261; JC7261.
DR RefSeq; NP_058590.1; NM_016894.3.
DR AlphaFoldDB; Q9WTJ5; -.
DR SMR; Q9WTJ5; -.
DR ComplexPortal; CPX-3149; CGRP receptor complex.
DR ComplexPortal; CPX-3235; Amylin receptor 1 complex.
DR STRING; 10090.ENSMUSP00000095253; -.
DR GuidetoPHARMACOLOGY; 51; -.
DR iPTMnet; Q9WTJ5; -.
DR PhosphoSitePlus; Q9WTJ5; -.
DR MaxQB; Q9WTJ5; -.
DR PaxDb; Q9WTJ5; -.
DR PRIDE; Q9WTJ5; -.
DR ProteomicsDB; 255091; -.
DR Antibodypedia; 34486; 234 antibodies from 39 providers.
DR DNASU; 51801; -.
DR Ensembl; ENSMUST00000097648; ENSMUSP00000095253; ENSMUSG00000034353.
DR GeneID; 51801; -.
DR KEGG; mmu:51801; -.
DR UCSC; uc007bzx.2; mouse.
DR CTD; 10267; -.
DR MGI; MGI:1858418; Ramp1.
DR VEuPathDB; HostDB:ENSMUSG00000034353; -.
DR eggNOG; ENOG502S0TC; Eukaryota.
DR GeneTree; ENSGT00940000159224; -.
DR HOGENOM; CLU_116349_3_0_1; -.
DR InParanoid; Q9WTJ5; -.
DR OMA; CYWPNRM; -.
DR OrthoDB; 1432933at2759; -.
DR PhylomeDB; Q9WTJ5; -.
DR TreeFam; TF333286; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
DR BioGRID-ORCS; 51801; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ramp1; mouse.
DR PRO; PR:Q9WTJ5; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9WTJ5; protein.
DR Bgee; ENSMUSG00000034353; Expressed in temporalis muscle and 211 other tissues.
DR ExpressionAtlas; Q9WTJ5; baseline and differential.
DR Genevisible; Q9WTJ5; MM.
DR GO; GO:0150056; C:amylin receptor complex 1; ISO:MGI.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:1990406; C:CGRP receptor complex; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0097643; F:amylin receptor activity; ISO:MGI.
DR GO; GO:1990407; F:calcitonin gene-related peptide binding; ISO:MGI.
DR GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; ISO:MGI.
DR GO; GO:0015026; F:coreceptor activity; IDA:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; ISO:MGI.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:MGI.
DR GO; GO:0006816; P:calcium ion transport; ISO:MGI.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IPI:MGI.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
DR GO; GO:0060050; P:positive regulation of protein glycosylation; ISO:MGI.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
DR GO; GO:0015031; P:protein transport; ISO:MGI.
DR GO; GO:0031623; P:receptor internalization; ISO:MGI.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; -; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; PTHR14076; 1.
DR Pfam; PF04901; RAMP; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..148
FT /note="Receptor activity-modifying protein 1"
FT /id="PRO_0000030169"
FT TOPO_DOM 27..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 27..82
FT /evidence="ECO:0000250"
FT DISULFID 40..72
FT /evidence="ECO:0000250"
FT DISULFID 57..104
FT /evidence="ECO:0000250"
SQ SEQUENCE 148 AA; 16892 MW; 5EC97385EA11DF97 CRC64;
MAPGLRGLPR CGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKENMET IGKTLWCDWG
KTIQSYGELT YCTKHVAHTI GCFWPNPEVD RFFIAVHHRY FSKCPISGRA LRDPPNSILC
PFIALPITVT LLMTALVVWR SKRTEGIV
