RAMP1_RAT
ID RAMP1_RAT Reviewed; 148 AA.
AC Q9JJ74;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Receptor activity-modifying protein 1;
DE Flags: Precursor;
GN Name=Ramp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11230971; DOI=10.1016/s0008-6363(00)00291-1;
RA Tomoda Y., Kikumoto K., Isumi Y., Katafuchi T., Tanaka A., Kangawa K.,
RA Dohi K., Minamino N.;
RT "Cardiac fibroblasts are major production and target cells of
RT adrenomedullin in the heart in vitro.";
RL Cardiovasc. Res. 49:721-730(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Heart;
RX PubMed=11556887; DOI=10.1046/j.0953-816x.2001.01688.x;
RA Oliver K.R., Kane S.A., Salvatore C.A., Mallee J.J., Kinsey A.M.,
RA Koblan K.S., Keyvan-Fouladi N., Heavens R.P., Wainwright A., Jacobson M.,
RA Dickerson I.M., Hill R.G.;
RT "Cloning, characterization and central nervous system distribution of
RT receptor activity modifying proteins in the rat.";
RL Eur. J. Neurosci. 14:618-628(2001).
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC calcitonin-gene-related peptide (CGRP) together with CALCRL.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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DR EMBL; AB042887; BAB03504.1; -; mRNA.
DR EMBL; AF181550; AAG09434.1; -; mRNA.
DR PIR; JC7235; JC7235.
DR RefSeq; NP_113833.1; NM_031645.1.
DR AlphaFoldDB; Q9JJ74; -.
DR SMR; Q9JJ74; -.
DR BioGRID; 248698; 3.
DR ComplexPortal; CPX-246; Amylin receptor 1 complex.
DR ComplexPortal; CPX-248; CGRP receptor complex.
DR STRING; 10116.ENSRNOP00000027012; -.
DR ChEMBL; CHEMBL2109240; -.
DR GuidetoPHARMACOLOGY; 51; -.
DR PaxDb; Q9JJ74; -.
DR PRIDE; Q9JJ74; -.
DR GeneID; 58965; -.
DR KEGG; rno:58965; -.
DR UCSC; RGD:61870; rat.
DR CTD; 10267; -.
DR RGD; 61870; Ramp1.
DR VEuPathDB; HostDB:ENSRNOG00000019926; -.
DR eggNOG; ENOG502S0TC; Eukaryota.
DR HOGENOM; CLU_116349_3_0_1; -.
DR InParanoid; Q9JJ74; -.
DR OMA; CYWPNRM; -.
DR OrthoDB; 1432933at2759; -.
DR PhylomeDB; Q9JJ74; -.
DR TreeFam; TF333286; -.
DR Reactome; R-RNO-419812; Calcitonin-like ligand receptors.
DR PRO; PR:Q9JJ74; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000019926; Expressed in thymus and 20 other tissues.
DR Genevisible; Q9JJ74; RN.
DR GO; GO:0150056; C:amylin receptor complex 1; ISO:RGD.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:1990406; C:CGRP receptor complex; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0043235; C:receptor complex; ISO:RGD.
DR GO; GO:0097643; F:amylin receptor activity; ISO:RGD.
DR GO; GO:1990407; F:calcitonin gene-related peptide binding; ISO:RGD.
DR GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; ISO:RGD.
DR GO; GO:0015026; F:coreceptor activity; IDA:RGD.
DR GO; GO:0001664; F:G protein-coupled receptor binding; NAS:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:RGD.
DR GO; GO:0001525; P:angiogenesis; ISO:RGD.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:RGD.
DR GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0032092; P:positive regulation of protein binding; IDA:RGD.
DR GO; GO:0060050; P:positive regulation of protein glycosylation; ISO:RGD.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISO:RGD.
DR GO; GO:0015031; P:protein transport; ISO:RGD.
DR GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.150.510; -; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; PTHR14076; 1.
DR Pfam; PF04901; RAMP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..148
FT /note="Receptor activity-modifying protein 1"
FT /id="PRO_0000030170"
FT TOPO_DOM 27..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 27..82
FT /evidence="ECO:0000250"
FT DISULFID 40..72
FT /evidence="ECO:0000250"
FT DISULFID 57..104
FT /evidence="ECO:0000250"
SQ SEQUENCE 148 AA; 16815 MW; F0A4A612DAF60075 CRC64;
MAPGLRGLPR RGLWLLLAHH LFMVTACRDP DYGTLIQELC LSRFKEDMET IGKTLWCDWG
KTIGSYGELT HCTKLVANKI GCFWPNPEVD KFFIAVHHRY FSKCPVSGRA LRDPPNSILC
PFIVLPITVT LLMTALVVWR SKRTEGIV
