RAMP2_RAT
ID RAMP2_RAT Reviewed; 182 AA.
AC Q9JHJ1;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Receptor activity-modifying protein 2;
DE Flags: Precursor;
GN Name=Ramp2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11230971; DOI=10.1016/s0008-6363(00)00291-1;
RA Tomoda Y., Kikumoto K., Isumi Y., Katafuchi T., Tanaka A., Kangawa K.,
RA Dohi K., Minamino N.;
RT "Cardiac fibroblasts are major production and target cells of
RT adrenomedullin in the heart in vitro.";
RL Cardiovasc. Res. 49:721-730(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=10733909; DOI=10.1006/bbrc.2000.2390;
RA Nagae T., Mukoyama M., Sugawara A., Mori K., Yahata K., Kasahara M.,
RA Suganami T., Makino H., Fujinaga Y., Yoshioka T., Tanaka I., Nakao K.;
RT "Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP
RT receptor: cloning and upregulation in obstructive nephropathy.";
RL Biochem. Biophys. Res. Commun. 270:89-93(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Sprague-Dawley; TISSUE=Heart;
RX PubMed=11556887; DOI=10.1046/j.0953-816x.2001.01688.x;
RA Oliver K.R., Kane S.A., Salvatore C.A., Mallee J.J., Kinsey A.M.,
RA Koblan K.S., Keyvan-Fouladi N., Heavens R.P., Wainwright A., Jacobson M.,
RA Dickerson I.M., Hill R.G.;
RT "Cloning, characterization and central nervous system distribution of
RT receptor activity modifying proteins in the rat.";
RL Eur. J. Neurosci. 14:618-628(2001).
CC -!- FUNCTION: Transports the calcitonin gene-related peptide type 1
CC receptor (CALCRL) to the plasma membrane. Acts as a receptor for
CC adrenomedullin (AM) together with CALCRL.
CC {ECO:0000269|PubMed:11556887}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP2.
CC {ECO:0000250|UniProtKB:O60895}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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DR EMBL; AB042888; BAB03505.1; -; mRNA.
DR EMBL; AB030943; BAA94426.1; -; mRNA.
DR EMBL; AF181551; AAG09435.1; -; mRNA.
DR PIR; JC7236; JC7236.
DR RefSeq; NP_113834.1; NM_031646.1.
DR AlphaFoldDB; Q9JHJ1; -.
DR SMR; Q9JHJ1; -.
DR BioGRID; 248699; 1.
DR ComplexPortal; CPX-244; Adrenomedullin receptor AM1 complex.
DR ComplexPortal; CPX-247; Amylin receptor 2 complex.
DR STRING; 10116.ENSRNOP00000043210; -.
DR GuidetoPHARMACOLOGY; 52; -.
DR GlyGen; Q9JHJ1; 3 sites.
DR iPTMnet; Q9JHJ1; -.
DR PhosphoSitePlus; Q9JHJ1; -.
DR PaxDb; Q9JHJ1; -.
DR GeneID; 58966; -.
DR KEGG; rno:58966; -.
DR UCSC; RGD:61872; rat.
DR CTD; 10266; -.
DR RGD; 61872; Ramp2.
DR VEuPathDB; HostDB:ENSRNOG00000020441; -.
DR eggNOG; ENOG502S5WC; Eukaryota.
DR InParanoid; Q9JHJ1; -.
DR OMA; CDWAVIS; -.
DR OrthoDB; 1482534at2759; -.
DR PhylomeDB; Q9JHJ1; -.
DR Reactome; R-RNO-419812; Calcitonin-like ligand receptors.
DR PRO; PR:Q9JHJ1; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000020415; Expressed in lung and 19 other tissues.
DR ExpressionAtlas; Q9JHJ1; baseline and differential.
DR Genevisible; Q9JHJ1; RN.
DR GO; GO:1903143; C:adrenomedullin receptor complex; ISO:RGD.
DR GO; GO:0150057; C:amylin receptor complex 2; ISO:RGD.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0043235; C:receptor complex; ISS:UniProtKB.
DR GO; GO:1990409; F:adrenomedullin binding; ISO:RGD.
DR GO; GO:0001605; F:adrenomedullin receptor activity; ISO:RGD.
DR GO; GO:0015026; F:coreceptor activity; IDA:RGD.
DR GO; GO:0001664; F:G protein-coupled receptor binding; NAS:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0034333; P:adherens junction assembly; ISS:UniProtKB.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; ISO:RGD.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:RGD.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0070831; P:basement membrane assembly; ISS:UniProtKB.
DR GO; GO:0070830; P:bicellular tight junction assembly; ISS:UniProtKB.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEP:RGD.
DR GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISS:UniProtKB.
DR GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0032092; P:positive regulation of protein binding; IDA:RGD.
DR GO; GO:2001214; P:positive regulation of vasculogenesis; ISO:RGD.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR GO; GO:0031623; P:receptor internalization; IDA:UniProtKB.
DR GO; GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR GO; GO:0032570; P:response to progesterone; IEP:RGD.
DR GO; GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.
DR GO; GO:0097084; P:vascular associated smooth muscle cell development; ISS:UniProtKB.
DR GO; GO:0001570; P:vasculogenesis; ISS:UniProtKB.
DR Gene3D; 1.10.150.510; -; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; PTHR14076; 1.
DR Pfam; PF04901; RAMP; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..45
FT /evidence="ECO:0000255"
FT CHAIN 46..182
FT /note="Receptor activity-modifying protein 2"
FT /id="PRO_0000030174"
FT TOPO_DOM 46..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 76..106
FT /evidence="ECO:0000250"
FT DISULFID 91..138
FT /evidence="ECO:0000250"
SQ SEQUENCE 182 AA; 20300 MW; 6A506053D7EE0748 CRC64;
MAPLRVERAP GGSQLAVTSA QRPAALRLPP LLLLLLLLLL GAVSTSPESL NQSHPTEDSL
LSKGKMEDYE TNVLPCWYYY KTSMDSVKDW CNWTLISRYY SNLRYCLEYE ADKFGLGFPN
PLAESIILEA HLIHFANCSL VQPTFSDPPE DVLLAMIIAP ICLIPFLVTL VVWRSKDGDA
QA
