ID   RAMP3_CAVPO             Reviewed;         146 AA.
AC   Q8R4C4;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Receptor activity-modifying protein 3;
DE   Flags: Precursor;
GN   Name=RAMP3;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Derst C., Preisig-Mueller R., Daut J.;
RT   "Cloning and sequencing of guinea pig amylin, calcitonin, CGRP and
RT   adrenomedullin receptor subunits.";
RL   Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in cardioprotection by reducing cardiac
CC       hypertrophy and perivascular fibrosis in a GPER1-dependent manner.
CC       Transports the calcitonin gene-related peptide type 1 receptor (CALCRL)
CC       and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin
CC       (AM) together with CALCRL (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of CALCRL and RAMP3. Interacts with GPER1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Single-pass
CC       type I membrane protein {ECO:0000250}. Note=Moves from intracellular
CC       puncta to the plasma membrane in a RAMP3-dependent manner.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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DR   EMBL; AF484221; AAL91560.1; -; mRNA.
DR   RefSeq; NP_001166482.1; NM_001173011.1.
DR   AlphaFoldDB; Q8R4C4; -.
DR   SMR; Q8R4C4; -.
DR   STRING; 10141.ENSCPOP00000012027; -.
DR   GeneID; 100135612; -.
DR   KEGG; cpoc:100135612; -.
DR   CTD; 10268; -.
DR   eggNOG; ENOG502S3C2; Eukaryota.
DR   HOGENOM; CLU_116349_3_1_1; -.
DR   InParanoid; Q8R4C4; -.
DR   OMA; FTNCTEE; -.
DR   OrthoDB; 1432933at2759; -.
DR   TreeFam; TF333286; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR   GO; GO:0086103; P:G protein-coupled receptor signaling pathway involved in heart process; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 1.10.150.510; -; 1.
DR   InterPro; IPR006985; RAMP.
DR   InterPro; IPR038126; RAMP_sf.
DR   PANTHER; PTHR14076; PTHR14076; 1.
DR   Pfam; PF04901; RAMP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..146
FT                   /note="Receptor activity-modifying protein 3"
FT                   /id="PRO_0000030175"
FT   TOPO_DOM        22..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        38..70
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..102
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   146 AA;  16869 MW;  4CECF6DABB609E99 CRC64;
     MGTRSRRPQL LWLLLLCGTC ARVCGCNETR MLERLPRCGK TFAERMREVA VWKWCDLSQF
     IVFYESFTNC TEEETVVVGC YWPNPLAQGF ITGVHRQFFS NCTVDRTHWE DPPDEVLIPL
     IAVPILLTVA MTGLVVWRSK RTDQLP