RAMP3_RAT
ID RAMP3_RAT Reviewed; 147 AA.
AC Q9JJ73;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Receptor activity-modifying protein 3;
DE Flags: Precursor;
GN Name=Ramp3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=11230971; DOI=10.1016/s0008-6363(00)00291-1;
RA Tomoda Y., Kikumoto K., Isumi Y., Katafuchi T., Tanaka A., Kangawa K.,
RA Dohi K., Minamino N.;
RT "Cardiac fibroblasts are major production and target cells of
RT adrenomedullin in the heart in vitro.";
RL Cardiovasc. Res. 49:721-730(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Sprague-Dawley; TISSUE=Heart;
RX PubMed=11556887; DOI=10.1046/j.0953-816x.2001.01688.x;
RA Oliver K.R., Kane S.A., Salvatore C.A., Mallee J.J., Kinsey A.M.,
RA Koblan K.S., Keyvan-Fouladi N., Heavens R.P., Wainwright A., Jacobson M.,
RA Dickerson I.M., Hill R.G.;
RT "Cloning, characterization and central nervous system distribution of
RT receptor activity modifying proteins in the rat.";
RL Eur. J. Neurosci. 14:618-628(2001).
CC -!- FUNCTION: Plays a role in cardioprotection by reducing cardiac
CC hypertrophy and perivascular fibrosis in a GPER1-dependent manner.
CC Transports the calcitonin gene-related peptide type 1 receptor (CALCRL)
CC and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin
CC (AM) together with CALCRL. {ECO:0000269|PubMed:11556887}.
CC -!- SUBUNIT: Heterodimer of CALCRL and RAMP3. Interacts with GPER1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Single-pass
CC type I membrane protein {ECO:0000250}. Note=Moves from intracellular
CC puncta to the plasma membrane in a RAMP3-dependent manner.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RAMP family. {ECO:0000305}.
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DR EMBL; AB042889; BAB03506.1; -; mRNA.
DR EMBL; AF181552; AAG09436.2; -; mRNA.
DR RefSeq; NP_064485.2; NM_020100.2.
DR AlphaFoldDB; Q9JJ73; -.
DR SMR; Q9JJ73; -.
DR ComplexPortal; CPX-245; Adrenomedullin receptor AM2 complex.
DR ComplexPortal; CPX-249; Amylin receptor 3 complex.
DR STRING; 10116.ENSRNOP00000010866; -.
DR GuidetoPHARMACOLOGY; 53; -.
DR GlyGen; Q9JJ73; 4 sites.
DR PaxDb; Q9JJ73; -.
DR Ensembl; ENSRNOT00000086468; ENSRNOP00000074204; ENSRNOG00000053766.
DR GeneID; 56820; -.
DR KEGG; rno:56820; -.
DR UCSC; RGD:61873; rat.
DR CTD; 10268; -.
DR RGD; 61873; Ramp3.
DR eggNOG; ENOG502S3C2; Eukaryota.
DR GeneTree; ENSGT00940000161026; -.
DR HOGENOM; CLU_116349_3_1_1; -.
DR InParanoid; Q9JJ73; -.
DR OMA; FTNCTEE; -.
DR OrthoDB; 1432933at2759; -.
DR PhylomeDB; Q9JJ73; -.
DR TreeFam; TF333286; -.
DR Reactome; R-RNO-419812; Calcitonin-like ligand receptors.
DR PRO; PR:Q9JJ73; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000053766; Expressed in adult mammalian kidney and 18 other tissues.
DR Genevisible; Q9JJ73; RN.
DR GO; GO:1903143; C:adrenomedullin receptor complex; ISO:RGD.
DR GO; GO:0150058; C:amylin receptor complex 3; ISO:RGD.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0043235; C:receptor complex; ISO:RGD.
DR GO; GO:0001605; F:adrenomedullin receptor activity; ISO:RGD.
DR GO; GO:0097643; F:amylin receptor activity; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IDA:RGD.
DR GO; GO:0001664; F:G protein-coupled receptor binding; NAS:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; ISO:RGD.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:RGD.
DR GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0038041; P:cross-receptor inhibition within G protein-coupled receptor heterodimer; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0086103; P:G protein-coupled receptor signaling pathway involved in heart process; ISS:UniProtKB.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:1905665; P:positive regulation of calcium ion import across plasma membrane; ISO:RGD.
DR GO; GO:0010942; P:positive regulation of cell death; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR GO; GO:0010739; P:positive regulation of protein kinase A signaling; ISO:RGD.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISS:UniProtKB.
DR GO; GO:0001921; P:positive regulation of receptor recycling; ISO:RGD.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISO:RGD.
DR GO; GO:0015031; P:protein transport; ISO:RGD.
DR GO; GO:0031623; P:receptor internalization; ISO:RGD.
DR GO; GO:1904645; P:response to amyloid-beta; ISO:RGD.
DR Gene3D; 1.10.150.510; -; 1.
DR InterPro; IPR006985; RAMP.
DR InterPro; IPR038126; RAMP_sf.
DR PANTHER; PTHR14076; PTHR14076; 1.
DR Pfam; PF04901; RAMP; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..147
FT /note="Receptor activity-modifying protein 3"
FT /id="PRO_0000030178"
FT TOPO_DOM 23..117
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 39..71
FT /evidence="ECO:0000250"
FT DISULFID 56..103
FT /evidence="ECO:0000250"
SQ SEQUENCE 147 AA; 16781 MW; FCD518954AC5E52B CRC64;
MATPAQRLHL LPLLLLLCGE CAQVCGCNET GMLERLPRCG KAFAEMMQKV DVWKWCNLSE
FIVYYESFTN CTEMETNIVG CYWPNPLAQS FITGIHRQFF SNCTVDRTHW EDPPDEVLIP
LIAVPVLLTV AMAGLVVWRS KRTDRLL
