ID   RAN1A_LOTJA             Reviewed;         209 AA.
AC   P54765;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=GTP-binding nuclear protein Ran1A;
DE   Flags: Fragment;
GN   Name=RAN1A;
OS   Lotus japonicus (Lotus corniculatus var. japonicus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; robinioid clade; Loteae; Lotus.
OX   NCBI_TaxID=34305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Gifu / B-129; TISSUE=Root nodule;
RX   PubMed=9076991; DOI=10.1046/j.1365-313x.1997.11020237.x;
RA   Borg S., Brandstrup B., Jensen T.J., Poulsen C.;
RT   "Identification of new protein species among 33 different small GTP-binding
RT   proteins encoded by cDNAs from Lotus japonicus, and expression of
RT   corresponding mRNAs in developing root nodules.";
RL   Plant J. 11:237-250(1997).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC       pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000305}.
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DR   EMBL; Z73959; CAA98187.1; -; mRNA.
DR   AlphaFoldDB; P54765; -.
DR   SMR; P54765; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24071; PTHR24071; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT   CHAIN           <1..209
FT                   /note="GTP-binding nuclear protein Ran1A"
FT                   /id="PRO_0000208720"
FT   REGION          187..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         9..16
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         59
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         113..116
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         141..143
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   NON_TER         1
SQ   SEQUENCE   209 AA;  23787 MW;  E5CAB4AFEF9AF6D5 CRC64;
     NFKLVIVGDG GTGKTTFVKR HLTGEFEKKY EPTIGVEVHP LDFFTNCGKI RFYCWDTAGQ
     EKFGGLRDGY YIHGQCAIIM FDVTARLTYK NVPTWHRDLC RVCENIPIVL CGNKVDVKNR
     QVKAKQVTFH RKKNLQYYEI SAKSNYNFEK PFLYLARKLA GDPNLHFVES PALAPPEVQI
     DLAAQQQHEA ELAQAASQPL PDDDDDAFD