ID   RAN2_SOLLC              Reviewed;         221 AA.
AC   P38547;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=GTP-binding nuclear protein Ran2;
DE   AltName: Full=Ras-related nuclear protein 2;
GN   Name=RAN2;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. VFNT Cherry LA1221;
RX   PubMed=8016079; DOI=10.1073/pnas.91.13.5863;
RA   Ach R.A., Gruissem W.;
RT   "A small nuclear GTP-binding protein from tomato suppresses a
RT   Schizosaccharomyces pombe cell-cycle mutant.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:5863-5867(1994).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC       pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000305}.
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DR   EMBL; L28714; AAC37403.1; -; mRNA.
DR   EMBL; L28715; AAC37404.1; -; mRNA.
DR   RefSeq; NP_001234020.1; NM_001247091.2.
DR   RefSeq; NP_001234023.1; NM_001247094.1.
DR   AlphaFoldDB; P38547; -.
DR   SMR; P38547; -.
DR   STRING; 4081.Solyc01g104680.2.1; -.
DR   PaxDb; P38547; -.
DR   GeneID; 778290; -.
DR   GeneID; 778291; -.
DR   KEGG; sly:778290; -.
DR   KEGG; sly:778291; -.
DR   eggNOG; KOG0096; Eukaryota.
DR   HOGENOM; CLU_041217_13_0_1; -.
DR   InParanoid; P38547; -.
DR   OrthoDB; 1083175at2759; -.
DR   PhylomeDB; P38547; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; P38547; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24071; PTHR24071; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..221
FT                   /note="GTP-binding nuclear protein Ran2"
FT                   /id="PRO_0000208723"
FT   BINDING         21..28
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         153..155
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
SQ   SEQUENCE   221 AA;  25161 MW;  9CAAB16E7D49B72B CRC64;
     MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV HPLDFFTNCG
     KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT YKNVPTWHRD LCRVCENIPI
     VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY EISAKSNYNF EKPFLYLARK LAGDGNLHFV
     ESPALAPPEV QIDLAAQALH EQELQAALNQ PLPDDDDEAF E