RAN4_ARATH
ID RAN4_ARATH Reviewed; 222 AA.
AC Q9FLQ3;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=GTP-binding nuclear protein Ran-4;
DE AltName: Full=Ras-related nuclear protein 4;
GN Name=RAN4; OrderedLocusNames=At5g55080; ORFNames=MCO15.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644670; DOI=10.1104/pp.013052;
RA Vernoud V., Horton A.C., Yang Z., Nielsen E.;
RT "Analysis of the small GTPase gene superfamily of Arabidopsis.";
RL Plant Physiol. 131:1191-1208(2003).
CC -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC Required for the import of protein into the nucleus and also for RNA
CC export. Involved in chromatin condensation and control of cell cycle
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB010071; BAB08577.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96578.1; -; Genomic_DNA.
DR RefSeq; NP_200319.1; NM_124890.1.
DR AlphaFoldDB; Q9FLQ3; -.
DR SMR; Q9FLQ3; -.
DR STRING; 3702.AT5G55080.1; -.
DR PaxDb; Q9FLQ3; -.
DR PRIDE; Q9FLQ3; -.
DR ProteomicsDB; 236211; -.
DR EnsemblPlants; AT5G55080.1; AT5G55080.1; AT5G55080.
DR GeneID; 835599; -.
DR Gramene; AT5G55080.1; AT5G55080.1; AT5G55080.
DR KEGG; ath:AT5G55080; -.
DR Araport; AT5G55080; -.
DR TAIR; locus:2161685; AT5G55080.
DR eggNOG; KOG0096; Eukaryota.
DR HOGENOM; CLU_041217_13_0_1; -.
DR InParanoid; Q9FLQ3; -.
DR OMA; RRVCKNI; -.
DR OrthoDB; 1083175at2759; -.
DR PhylomeDB; Q9FLQ3; -.
DR PRO; PR:Q9FLQ3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLQ3; baseline and differential.
DR Genevisible; Q9FLQ3; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0000054; P:ribosomal subunit export from nucleus; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002041; Ran_GTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR24071; PTHR24071; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00627; GTPRANTC4.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51418; RAN; 1.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..222
FT /note="GTP-binding nuclear protein Ran-4"
FT /id="PRO_0000347207"
FT BINDING 21..28
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 153..155
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
SQ SEQUENCE 222 AA; 25594 MW; 27B68F1F32CB8812 CRC64;
MALPNQQNVD LPTFKLLIVG DGGTGKTTFL KRHLTGEFEH NTEPTLGVDI YPLDFFTNRG
KIRFECWDTA GQEKYSGLKD AYYIHGQCAI IMFDVTARHT YMNIDRWYRD LRRVCKNIPI
VLCGNKVDVP SRQIKPKHVS YHRKKCLQYY EMSAKNNCNF EKPFLYLARR IAGDAKLSFV
ESPEAQIDNL DVESLQLLTV EAGTQPLLMT RISFEFNTLS IE