RAN5_LITCT
ID RAN5_LITCT Reviewed; 12 AA.
AC P82820;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 22-APR-2020, entry version 35.
DE RecName: Full=Ranatuerin-5 {ECO:0000303|PubMed:9784389};
OS Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8400;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Skin secretion;
RX PubMed=9784389; DOI=10.1006/bbrc.1998.9362;
RA Goraya J., Knoop F.C., Conlon J.M.;
RT "Ranatuerins: antimicrobial peptides isolated from the skin of the American
RT bullfrog, Rana catesbeiana.";
RL Biochem. Biophys. Res. Commun. 250:589-592(1998).
CC -!- FUNCTION: May act as an antimicrobial peptide. Show low antibacterial
CC activity against Gram-positive bacterium S.aureus (MIC>200 uM). Shows
CC no detectable hemolytic activity towards human erythrocytes.
CC {ECO:0000269|PubMed:9784389}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9784389}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:9784389}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Secreted.
FT PEPTIDE 1..12
FT /note="Ranatuerin-5"
FT /evidence="ECO:0000269|PubMed:9784389"
FT /id="PRO_0000043562"
SQ SEQUENCE 12 AA; 1335 MW; C8531D12A92735BD CRC64;
FLPIASLLGK YL
