ID   RANB9_XENTR             Reviewed;         548 AA.
AC   Q28FM1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Ran-binding protein 9;
DE            Short=RanBP9;
DE   AltName: Full=Ran-binding protein 10;
DE            Short=RanBP10;
DE   AltName: Full=Ran-binding protein M;
DE            Short=RanBPM;
GN   Name=ranbp9; Synonyms=ranbp10, ranbpm; ORFNames=TNeu108a21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as scaffolding protein, and as adapter protein to
CC       couple membrane receptors to intracellular signaling pathways. Acts as
CC       a mediator of cell spreading and actin cytoskeleton rearrangement. Core
CC       component of the CTLH E3 ubiquitin-protein ligase complex that mediates
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250|UniProtKB:Q96S59}.
CC   -!- SUBUNIT: Identified in the CTLH complex that contains at least MAEA,
CC       RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9
CC       and/or RANBP10. {ECO:0000250|UniProtKB:Q96S59}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P69566}. Cell
CC       membrane {ECO:0000250|UniProtKB:P69566}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P69566}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P69566}. Nucleus {ECO:0000250|UniProtKB:P69566}.
CC       Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:P69566}.
CC   -!- SIMILARITY: Belongs to the RANBP9/10 family. {ECO:0000305}.
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DR   EMBL; CR761896; CAJ83297.1; -; mRNA.
DR   RefSeq; NP_001037977.1; NM_001044512.1.
DR   AlphaFoldDB; Q28FM1; -.
DR   SMR; Q28FM1; -.
DR   STRING; 8364.ENSXETP00000020490; -.
DR   PaxDb; Q28FM1; -.
DR   GeneID; 733762; -.
DR   KEGG; xtr:733762; -.
DR   CTD; 10048; -.
DR   Xenbase; XB-GENE-494852; ranbp9.
DR   eggNOG; KOG1477; Eukaryota.
DR   HOGENOM; CLU_009129_4_1_1; -.
DR   InParanoid; Q28FM1; -.
DR   OMA; GRDGXWD; -.
DR   OrthoDB; 1106989at2759; -.
DR   PhylomeDB; Q28FM1; -.
DR   TreeFam; TF331658; -.
DR   Reactome; R-XTR-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-XTR-8851805; MET activates RAS signaling.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q28FM1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   CDD; cd12909; SPRY_RanBP9_10; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR013144; CRA_dom.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035782; SPRY_RanBP9/10.
DR   Pfam; PF10607; CLTH; 1.
DR   Pfam; PF08513; LisH; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00757; CRA; 1.
DR   SMART; SM00668; CTLH; 1.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Nucleus; Reference proteome.
FT   CHAIN           1..548
FT                   /note="Ran-binding protein 9"
FT                   /id="PRO_0000305235"
FT   DOMAIN          2..189
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   DOMAIN          217..249
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          255..312
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   548 AA;  60403 MW;  ED08C495FC4479C7 CRC64;
     MSSPPLHGLS SGGHLSRDPP PRSWSPRDKC SYLGLSHGNL RVHYKGHGKT SKDAASVRST
     HPIPAACGIF YFEVKIISKG RDGYMGIGLS TQGVNLSRLP GWDKHSYGYH GDDGHSFCSS
     GTGQPYGPTF TTGDVIGCCV NLIDNTCFYT KNGHSLGIAF TDLPPNLYPT VGLQTPGEVV
     DANFGQSPFV FDIEDYIREW RTKIQAQIER FPVGGEWQSM IQRMVSSYLV HHGYCSTAEA
     FAKSTDQTVQ EELASIKNRQ RIQKLVLSGR MGEAIETTQQ LYPSLLERNP NLLFTLKVRQ
     FIEMVNGTDS EVRCLGNRSL KSLDGCSGSD SNCSNGIISN KAHQTHCHSK SQSSNLNVTE
     LNSINMTMSH QLNSYSSNDV EMETDHYSNG FSASTSNGFL NGSSRHEPEL EECDTEMEVD
     TSHGRRQLCG GSQAAVERMI CFGRELQAMS EQLRRERGKN ATNKNMLKDA FSLLAYSDPW
     NSPVGYQLDP IQREHVCSSL NSAILDIHNL PKQPPLSLAL EQASQCLEMM AQCGIGSCAF
     ARVADYLH