RANBM_ARATH
ID RANBM_ARATH Reviewed; 467 AA.
AC F4HYD7; Q8VYQ8; Q9C8P9;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Ran-binding protein M homolog {ECO:0000305};
DE Short=AtRanBPM {ECO:0000303|PubMed:22676313};
GN Name=RANBPM {ECO:0000303|PubMed:22676313};
GN OrderedLocusNames=At1g35470 {ECO:0000312|Araport:AT1G35470};
GN ORFNames=F12A4.1 {ECO:0000312|EMBL:AAG52111.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH WDR36; WDS; GID8;
RP MAEA AND RMD5, AND SUBCELLULAR LOCATION.
RX PubMed=22676313; DOI=10.1186/1471-2229-12-83;
RA Tomastikova E., Cenklova V., Kohoutova L., Petrovska B., Vachova L.,
RA Halada P., Kocarova G., Binarova P.;
RT "Interactions of an Arabidopsis RanBPM homologue with LisH-CTLH domain
RT proteins revealed high conservation of CTLH complexes in eukaryotes.";
RL BMC Plant Biol. 12:83-83(2012).
CC -!- SUBUNIT: Interacts with WDR36, WDS, GID8, MAEA and RMD5.
CC {ECO:0000269|PubMed:22676313}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22676313}. Nucleus
CC {ECO:0000269|PubMed:22676313}. Cytoplasm, perinuclear region
CC {ECO:0000269|PubMed:22676313}. Note=Associates predominantly in the
CC form of large cytoplasmic complexes. {ECO:0000269|PubMed:22676313}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4HYD7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4HYD7-2; Sequence=VSP_059163;
CC -!- SIMILARITY: Belongs to the RANBP9/10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52111.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC023064; AAG52111.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31799.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31798.1; -; Genomic_DNA.
DR EMBL; AY070090; AAL49784.1; -; mRNA.
DR EMBL; AY096710; AAM20344.1; -; mRNA.
DR PIR; G86475; G86475.
DR RefSeq; NP_174777.2; NM_103241.3. [F4HYD7-2]
DR RefSeq; NP_973963.1; NM_202234.3. [F4HYD7-1]
DR AlphaFoldDB; F4HYD7; -.
DR SMR; F4HYD7; -.
DR STRING; 3702.AT1G35470.2; -.
DR PaxDb; F4HYD7; -.
DR PRIDE; F4HYD7; -.
DR ProteomicsDB; 236861; -. [F4HYD7-1]
DR DNASU; 840440; -.
DR EnsemblPlants; AT1G35470.1; AT1G35470.1; AT1G35470. [F4HYD7-2]
DR EnsemblPlants; AT1G35470.2; AT1G35470.2; AT1G35470. [F4HYD7-1]
DR GeneID; 840440; -.
DR Gramene; AT1G35470.1; AT1G35470.1; AT1G35470. [F4HYD7-2]
DR Gramene; AT1G35470.2; AT1G35470.2; AT1G35470. [F4HYD7-1]
DR KEGG; ath:AT1G35470; -.
DR Araport; AT1G35470; -.
DR TAIR; locus:2008683; AT1G35470.
DR eggNOG; KOG1477; Eukaryota.
DR InParanoid; F4HYD7; -.
DR OMA; GCCINFV; -.
DR PRO; PR:F4HYD7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HYD7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR013144; CRA_dom.
DR InterPro; IPR024964; CTLH/CRA.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR Pfam; PF10607; CLTH; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00757; CRA; 1.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..467
FT /note="Ran-binding protein M homolog"
FT /id="PRO_0000442056"
FT DOMAIN 31..219
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT DOMAIN 244..276
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT DOMAIN 295..353
FT /note="CTLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 347..348
FT /note="Missing (in isoform 2)"
FT /id="VSP_059163"
SQ SEQUENCE 467 AA; 52349 MW; F06370D493D9A4B7 CRC64;
MNSSPPPANS ANGDTTNNGE NGQDLNLNFL DKIRLSAKRD AKEDEGEELP TELNTINSAG
GFLVVSPDKL SVKYTNTNLH GHDVGVVQAN KPAPIKCLTY YFEIFVKDSG IKGQIAIGFT
KESFKMRRQP GWEVNSCGYH GDDGYLYRGQ GKGEPFGPKF TKDDAVGGGI NYASQEFFFT
KNGTIVGKIP KDIRGHLFPT VAVHSQNEEV LVNFGKKKFA FDIKGYEASE RNKQQLAIEK
ISIPPNIGYG LVKTYLLHYG YEETLDAFNL ATKNTVPPIH IDQENAIDED DSSYALKQRK
NLRQLVRNGE IDTALAELQK LYPQIVQDDK SVVCFLLHCQ KFIELVRVGK LEEGVNYGRL
ELAKFVGLTG FQDIVEDCFA LLAYEKPEES SVWYFLEDSQ RELVADAVNA AILSTNPNKK
DVQRSCHLQS HLEKLLRQLT VCCLERRSLN GDQGETFRLR HVLNNNR
