ID   RANC_LITPI              Reviewed;          11 AA.
AC   P08951;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   02-DEC-2020, entry version 60.
DE   RecName: Full=Ranatensin-C;
OS   Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8404;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT
RP   MET-11.
RC   TISSUE=Skin secretion;
RX   PubMed=6141890; DOI=10.1016/0742-8413(84)90137-3;
RA   Erspamer V., Erspamer G.F., Mazzanti G., Endean R.;
RT   "Active peptides in the skins of one hundred amphibian species from
RT   Australia and Papua New Guinea.";
RL   Comp. Biochem. Physiol. 77C:99-108(1984).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..11
FT                   /note="Ranatensin-C"
FT                   /id="PRO_0000043495"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:6141890"
FT   MOD_RES         11
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:6141890"
SQ   SEQUENCE   11 AA;  1303 MW;  D6C981BD61ADC366 CRC64;
     QTPQWATGHF M