RAN_BRUMA
ID RAN_BRUMA Reviewed; 215 AA.
AC P38542; A8Q704;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=GTP-binding nuclear protein Ran;
DE AltName: Full=GTPase Ran;
DE AltName: Full=Ras-like protein TC4;
GN ORFNames=Bm1_44725;
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1484550; DOI=10.1016/0166-6851(92)90175-j;
RA Dissanayake S., Xu M., Piessens W.F.;
RT "Filarial parasites contain a ras homolog of the TC4/ran/Spil family.";
RL Mol. Biochem. Parasitol. 56:259-268(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
CC -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC Required for the import of protein into the nucleus and also for RNA
CC export. Involved in chromatin condensation and control of cell cycle
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC {ECO:0000305}.
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DR EMBL; M98810; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; DS239418; EDP30622.1; -; Genomic_DNA.
DR PIR; A48463; A48463.
DR RefSeq; XP_001900408.1; XM_001900373.1.
DR AlphaFoldDB; P38542; -.
DR SMR; P38542; -.
DR STRING; 6279.P38542; -.
DR EnsemblMetazoa; Bm4731.1; Bm4731.1; WBGene00224992.
DR GeneID; 6103829; -.
DR KEGG; bmy:BM_BM4731; -.
DR WBParaSite; Bm4731.1; Bm4731.1; WBGene00224992.
DR CTD; 6103829; -.
DR WormBase; Bm4731; BM38293; WBGene00224992; Bma-ran-1.
DR InParanoid; P38542; -.
DR OrthoDB; 1083175at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR GO; GO:0048477; P:oogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002041; Ran_GTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR24071; PTHR24071; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00627; GTPRANTC4.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51418; RAN; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..215
FT /note="GTP-binding nuclear protein Ran"
FT /id="PRO_0000208707"
FT BINDING 17..24
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 35..41
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT BINDING 149..151
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62825"
FT CONFLICT 33
FT /note="E -> D (in Ref. 1; M98810)"
FT /evidence="ECO:0000305"
FT CONFLICT 86..87
FT /note="II -> FN (in Ref. 1; M98810)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="F -> S (in Ref. 1; M98810)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 215 AA; 24338 MW; 2091CC0B68B8C1A5 CRC64;
MATGDDIPTF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLI FHTNRGQIRF
NVWDTAGQEK FGGLRDGYYI QGQCAIIMFD VTARVTYKNV PNWHRDLVRV CENIPIVLCG
NKVDVKDRKV KAKTITFHRK KNLQYYDISA KSNYNFEKPF LWLARKLLGD PNLEFVAMPA
LAPPEVQMDP TMVAQYEQEI AAAANAELPD DDEDL
