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RAN_CAEEL
ID   RAN_CAEEL               Reviewed;         215 AA.
AC   O17915;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 171.
DE   RecName: Full=GTP-binding nuclear protein ran-1;
DE   AltName: Full=Ras-related nuclear protein 1;
GN   Name=ran-1; ORFNames=K01G5.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|EMBL:CAB07240.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Bristol N2 {ECO:0000269|PubMed:11909538};
RX   PubMed=11909538; DOI=10.1016/s0960-9822(02)00741-8;
RA   Bamba C., Bobinnec Y., Fukuda M., Nishida E.;
RT   "The GTPase Ran regulates chromosome positioning and nuclear envelope
RT   assembly in vivo.";
RL   Curr. Biol. 12:503-507(2002).
CC   -!- FUNCTION: Ran GTPase system comprises ran-1, ran-2 and ran-3 and is
CC       essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding
CC       protein that mediates the interaction between mitotic chromosomes and
CC       kinetochore microtubules. Plays a crucial role in nuclear envelope
CC       assembly at the end of each cell division. Required for the import of
CC       protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran
CC       (ran-1) complex (together with other proteins) acts as a component of a
CC       signal transmission pathway that detects unreplicated DNA.
CC       {ECO:0000269|PubMed:11909538}.
CC   -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC       pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- INTERACTION:
CC       O17915; Q86G90: npp-9; NbExp=6; IntAct=EBI-324099, EBI-313076;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11909538}.
CC       Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11909538}.
CC       Chromosome {ECO:0000269|PubMed:11909538}. Note=At interphase, ran-1 is
CC       localized to the nucleus and the nuclear envelope. At prometaphase,
CC       ran-1 is still localized to the nuclear envelope. When the nuclear
CC       envelope begins to disassemble at M phase (early metaphase), ran-1 is
CC       localized throughout the entire cell. At late metaphase, ran-1
CC       localizes to the kinetochore regions, this persists until anaphase. At
CC       telophase, ran-1 is localized around the decondensing chromosomes.
CC   -!- MISCELLANEOUS: Loss of ran-1 results in failure of correct attachment
CC       of kinetochore microtubules to mitotic chromosomes and the resultant
CC       loss of correct chromosome segregation. The number and the location of
CC       centrosomes are normal, and astral mictrotubules also seem unaffected.
CC       Nuclear envelope is not reestablished at the end of each cell division.
CC       {ECO:0000269|PubMed:11909538}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000305}.
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DR   EMBL; Z92803; CAB07240.1; -; Genomic_DNA.
DR   PIR; T23195; T23195.
DR   RefSeq; NP_499369.1; NM_066968.5.
DR   AlphaFoldDB; O17915; -.
DR   SMR; O17915; -.
DR   BioGRID; 41690; 55.
DR   DIP; DIP-25217N; -.
DR   IntAct; O17915; 16.
DR   STRING; 6239.K01G5.4; -.
DR   iPTMnet; O17915; -.
DR   EPD; O17915; -.
DR   PaxDb; O17915; -.
DR   PeptideAtlas; O17915; -.
DR   EnsemblMetazoa; K01G5.4.1; K01G5.4.1; WBGene00004302.
DR   GeneID; 176503; -.
DR   KEGG; cel:CELE_K01G5.4; -.
DR   UCSC; K01G5.4.1; c. elegans.
DR   CTD; 176503; -.
DR   WormBase; K01G5.4; CE16194; WBGene00004302; ran-1.
DR   eggNOG; KOG0096; Eukaryota.
DR   GeneTree; ENSGT00940000153786; -.
DR   HOGENOM; CLU_041217_13_0_1; -.
DR   InParanoid; O17915; -.
DR   OMA; TIVFHRK; -.
DR   OrthoDB; 1083175at2759; -.
DR   PhylomeDB; O17915; -.
DR   Reactome; R-CEL-1655829; Regulation of cholesterol biosynthesis by SREBP (SREBF).
DR   Reactome; R-CEL-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR   PRO; PR:O17915; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00004302; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0048477; P:oogenesis; IMP:WormBase.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24071; PTHR24071; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; GTP-binding;
KW   Kinetochore; Mitosis; Nucleotide-binding; Nucleus; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..215
FT                   /note="GTP-binding nuclear protein ran-1"
FT                   /id="PRO_0000208708"
FT   BINDING         17..24
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         67
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         121..124
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         149..151
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
SQ   SEQUENCE   215 AA;  24254 MW;  90B32613588745E5 CRC64;
     MSGGDGIPTF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLV FHTNRGQIRF
     NVWDTAGQEK FGGLRDGYYI QGQCAIIMFD VTARVTYKNV PNWHRDLARV CENIPIVLCG
     NKVDVKDRKV KAKTITFHRK KNLQYYDISA KSNYNFEKPF LWLARKLLGD PNLEFVAMPA
     LAPPEVQMDP AMIAEYEKDL DNAAKADLPD DDDDL
 
 
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