ID   RAN_GIAIN               Reviewed;         226 AA.
AC   P38543;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=GTP-binding nuclear protein Ran;
DE   AltName: Full=GTPase Ran;
DE   AltName: Full=Ras-like protein TC4;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30957 / WB;
RX   PubMed=8006038; DOI=10.1016/s0021-9258(17)32554-1;
RA   Chen L.-M., Chern Y., Ong S.-J., Tai J.-H.;
RT   "Molecular cloning and characterization of a ras-related gene of
RT   ran/tc4/spi1 subfamily in Giardia lamblia.";
RL   J. Biol. Chem. 269:17297-17304(1994).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC       pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U02589; AAA21426.1; -; Genomic_DNA.
DR   RefSeq; XP_001705159.1; XM_001705107.1.
DR   AlphaFoldDB; P38543; -.
DR   SMR; P38543; -.
DR   PRIDE; P38543; -.
DR   GeneID; 5698010; -.
DR   KEGG; gla:GL50803_0015869; -.
DR   VEuPathDB; GiardiaDB:DHA2_15869; -.
DR   VEuPathDB; GiardiaDB:GL50581_2747; -.
DR   VEuPathDB; GiardiaDB:GL50803_0015869; -.
DR   eggNOG; KOG0096; Eukaryota.
DR   OMA; TIVFHRK; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24071; PTHR24071; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT   CHAIN           1..226
FT                   /note="GTP-binding nuclear protein Ran"
FT                   /id="PRO_0000208712"
FT   BINDING         14..21
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         70
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         135..138
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         163..165
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
SQ   SEQUENCE   226 AA;  25421 MW;  11C4C803BC59E23D CRC64;
     MSDPISFKVI LVGDGATGKT TFVTRHITGE FRKQYISTIG VEIRQLPFYV AGQSCPNGRE
     VLLNVHDTAG QEKFGGLRDG YYVDSDACLL FFDVTNRVTY KNVESWYRDV FRICPTRRDA
     STGEEKPLAI VLVGNKCDVK DREIRTQTVK FHRSKNIPYV EISAKDNFNY ELPILSILRT
     LLNDPTIQFS QAPALLPADI GMDAATREQI NKDLEAVNNV PLPDDD