ID   RAN_TETPY               Reviewed;         223 AA.
AC   P41914;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=GTP-binding nuclear protein Ran;
DE   AltName: Full=GTPase Ran;
DE   AltName: Full=Ras-like protein TC4;
OS   Tetrahymena pyriformis.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5908;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=W;
RX   PubMed=8026746; DOI=10.1016/0378-1119(94)90215-1;
RA   Nagata K., Takemasa T., Alam S., Hattori T., Watanabe Y., Nozawa Y.;
RT   "Cloning of cDNAs encoding a cell-cycle-regulatory GTP-binding low-M(r)
RT   (GBLM) protein, Ran/TC4, from micronucleated Tetrahymena thermophila and
RT   amicronucleated Tetrahymena pyriformis.";
RL   Gene 144:123-125(1994).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Found in a nuclear export complex with RanGTP,
CC       exportin and pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000305}.
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DR   EMBL; D21825; BAA04849.1; -; mRNA.
DR   AlphaFoldDB; P41914; -.
DR   SMR; P41914; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24071; PTHR24071; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT   CHAIN           1..223
FT                   /note="GTP-binding nuclear protein Ran"
FT                   /id="PRO_0000208715"
FT   BINDING         19..26
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         69
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         123..126
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         151..153
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
SQ   SEQUENCE   223 AA;  25422 MW;  5474DADB5ABF0977 CRC64;
     MVDNKQDVVA EFKLVLVGDG GVGKTTFVTR HQTGEFEKRY IATQGVNVSN MILHTTKGAI
     RFNIWDTAGQ EKLGGLREGY YIGADAAIMM FDVTSRITYK NIPKWHKDLT RICENVPIVL
     VGNKVDSKDS KVKARQITFH RKRSLQYYDV SAKSNYQYEK PFLWILRKLT GDPNLNLVEG
     IALAPVDIHM TEDQIKQLQM EHDEAMNLAQ QGQLPDEEDD EFN