ID   RAN_TETTH               Reviewed;         225 AA.
AC   P41915;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=GTP-binding nuclear protein Ran;
DE   AltName: Full=GTPase Ran;
DE   AltName: Full=Ras-like protein TC4;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=B1868;
RX   PubMed=8026746; DOI=10.1016/0378-1119(94)90215-1;
RA   Nagata K., Takemasa T., Alam S., Hattori T., Watanabe Y., Nozawa Y.;
RT   "Cloning of cDNAs encoding a cell-cycle-regulatory GTP-binding low-M(r)
RT   (GBLM) protein, Ran/TC4, from micronucleated Tetrahymena thermophila and
RT   amicronucleated Tetrahymena pyriformis.";
RL   Gene 144:123-125(1994).
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Found in a nuclear export complex with RanGTP,
CC       exportin and pre-miRNA (By similarity). {ECO:0000250|UniProtKB:P62825}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D17748; BAA04600.1; -; mRNA.
DR   AlphaFoldDB; P41915; -.
DR   SMR; P41915; -.
DR   OMA; IRFNIWD; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR24071; PTHR24071; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51418; RAN; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Nucleus; Protein transport; Transport.
FT   CHAIN           1..225
FT                   /note="GTP-binding nuclear protein Ran"
FT                   /id="PRO_0000208716"
FT   BINDING         19..26
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         69
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         123..126
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
FT   BINDING         151..153
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P62825"
SQ   SEQUENCE   225 AA;  25649 MW;  69F8B8409AF703F8 CRC64;
     MVDNKQNVVA EFKLVLVGDG GVGKTTFVTR HQTGEFEKRY IATQGVNVSN MVLYTTKGPI
     RFNIWDTAGQ EKLGGLREGY YIGANAAIMM FDVTSRITYK NIPKWHKDLT RICENIPIVL
     VGNKVDSKDR KVKARQITFH RKRSLQYYDV SAKSNYQYEK PFLWILRKLT GDPTLNLVEG
     IALVAPDTEH VMTEDQIKQL EMEQAEAMNL AQQGVLPDDE DDEFN