RAP1B_CHICK
ID RAP1B_CHICK Reviewed; 184 AA.
AC Q5ZHX1;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Ras-related protein Rap-1b;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P61224};
DE Flags: Precursor;
GN Name=RAP1B; ORFNames=RCJMB04_32g9, RCJMB04_4h13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Probable GTP-binding protein that possesses GTPase activity.
CC May play a role in endothelial cell polarity and endothelial barrier
CC function (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P61224};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm, cytosol
CC {ECO:0000250}. Cell junction {ECO:0000250}. Note=May shuttle between
CC plasma membrane and cytosol. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000305}.
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DR EMBL; AJ719603; CAG31262.1; -; mRNA.
DR EMBL; AJ721013; CAG32672.1; -; mRNA.
DR RefSeq; NP_001007853.1; NM_001007852.1.
DR RefSeq; XP_015137180.1; XM_015281694.1.
DR AlphaFoldDB; Q5ZHX1; -.
DR SMR; Q5ZHX1; -.
DR STRING; 9031.ENSGALP00000002236; -.
DR PaxDb; Q5ZHX1; -.
DR Ensembl; ENSGALT00000016139; ENSGALP00000016120; ENSGALG00000009927.
DR GeneID; 417840; -.
DR KEGG; gga:417840; -.
DR CTD; 5908; -.
DR VEuPathDB; HostDB:geneid_417840; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000154429; -.
DR HOGENOM; CLU_041217_9_8_1; -.
DR InParanoid; Q5ZHX1; -.
DR OMA; CYRKQWV; -.
DR OrthoDB; 1353024at2759; -.
DR PhylomeDB; Q5ZHX1; -.
DR TreeFam; TF313014; -.
DR Reactome; R-GGA-354192; Integrin signaling.
DR Reactome; R-GGA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins.
DR Reactome; R-GGA-372708; p130Cas linkage to MAPK signaling for integrins.
DR Reactome; R-GGA-392517; Rap1 signalling.
DR Reactome; R-GGA-5674135; MAP2K and MAPK activation.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR Reactome; R-GGA-8875555; MET activates RAP1 and RAC1.
DR PRO; PR:Q5ZHX1; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000009927; Expressed in granulocyte and 14 other tissues.
DR ExpressionAtlas; Q5ZHX1; baseline and differential.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0071320; P:cellular response to cAMP; IBA:GO_Central.
DR GO; GO:2000301; P:negative regulation of synaptic vesicle exocytosis; IBA:GO_Central.
DR GO; GO:0032486; P:Rap protein signal transduction; IBA:GO_Central.
DR CDD; cd04175; Rap1; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038851; Rap1.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR020849; Small_GTPase_Ras-type.
DR PANTHER; PTHR24070; PTHR24070; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51421; RAS; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Cytoplasm; GTP-binding; Hydrolase;
KW Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein;
KW Prenylation; Reference proteome.
FT CHAIN 1..181
FT /note="Ras-related protein Rap-1b"
FT /id="PRO_0000260753"
FT PROPEP 182..184
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000260754"
FT MOTIF 32..40
FT /note="Effector region"
FT /evidence="ECO:0000305"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 57..61
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 116..119
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 179
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 181
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 181
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 184 AA; 20825 MW; CE976895E5965224 CRC64;
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG
TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL
EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS
CQLL
