RAP21_ARATH
ID RAP21_ARATH Reviewed; 153 AA.
AC Q8LC30; O23103; Q42165; Q9C630;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Ethylene-responsive transcription factor RAP2-1;
DE AltName: Full=Protein RELATED TO APETALA2 1;
GN Name=RAP2-1; Synonyms=ERF006; OrderedLocusNames=At1g46768;
GN ORFNames=F2G19.32;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-140.
RC STRAIN=cv. Columbia; TISSUE=Seed;
RA Raynal M., Grellet F., Laudie M., Meyer Y., Cooke R., Delseny M.;
RT "The Arabidopsis thaliana transcribed genome: the GDR cDNA program.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-153, AND TISSUE SPECIFICITY.
RX PubMed=9192694; DOI=10.1073/pnas.94.13.7076;
RA Okamuro J.K., Caster B., Villarroel R., Van Montagu M., Jofuku K.D.;
RT "The AP2 domain of APETALA2 defines a large new family of DNA binding
RT proteins in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:7076-7081(1997).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
CC -!- FUNCTION: Probably acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in flowers, leaves, and
CC stems, and at very low levels in roots. {ECO:0000269|PubMed:9192694}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. ERF
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50629.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC083835; AAG50629.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE32129.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59960.1; -; Genomic_DNA.
DR EMBL; BT024691; ABD57516.1; -; mRNA.
DR EMBL; AY086838; AAM63886.1; -; mRNA.
DR EMBL; Z27045; CAA81574.1; -; mRNA.
DR EMBL; AF003094; AAC49767.1; -; mRNA.
DR PIR; H96511; H96511.
DR RefSeq; NP_001322276.1; NM_001333265.1.
DR RefSeq; NP_564496.1; NM_103607.4.
DR AlphaFoldDB; Q8LC30; -.
DR SMR; Q8LC30; -.
DR BioGRID; 26342; 3.
DR STRING; 3702.AT1G46768.1; -.
DR PaxDb; Q8LC30; -.
DR PRIDE; Q8LC30; -.
DR ProteomicsDB; 225920; -.
DR EnsemblPlants; AT1G46768.1; AT1G46768.1; AT1G46768.
DR EnsemblPlants; AT1G46768.2; AT1G46768.2; AT1G46768.
DR GeneID; 841117; -.
DR Gramene; AT1G46768.1; AT1G46768.1; AT1G46768.
DR Gramene; AT1G46768.2; AT1G46768.2; AT1G46768.
DR KEGG; ath:AT1G46768; -.
DR Araport; AT1G46768; -.
DR TAIR; locus:2825842; AT1G46768.
DR eggNOG; ENOG502S0BY; Eukaryota.
DR HOGENOM; CLU_063331_7_2_1; -.
DR InParanoid; Q8LC30; -.
DR OMA; RDHCCSN; -.
DR OrthoDB; 1369964at2759; -.
DR PhylomeDB; Q8LC30; -.
DR PRO; PR:Q8LC30; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LC30; baseline and differential.
DR Genevisible; Q8LC30; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0009409; P:response to cold; IMP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR CDD; cd00018; AP2; 1.
DR Gene3D; 3.30.730.10; -; 1.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 1.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 1.
DR SUPFAM; SSF54171; SSF54171; 1.
DR PROSITE; PS51032; AP2_ERF; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Ethylene signaling pathway; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..153
FT /note="Ethylene-responsive transcription factor RAP2-1"
FT /id="PRO_0000297932"
FT DNA_BIND 30..87
FT /note="AP2/ERF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 26
FT /note="A -> D (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 31
FT /note="Y -> H (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="G -> R (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 82
FT /note="A -> T (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="Q -> K (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="D -> A (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 99..103
FT /note="AATTA -> GDTSG (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
FT CONFLICT 107
FT /note="A -> G (in Ref. 5; CAA81574)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 17241 MW; 86350D269CD0D6E8 CRC64;
MEREQEESTM RKRRQPPQEE VPNHVATRKP YRGIRRRKWG KWVAEIREPN KRSRLWLGSY
TTDIAAARAY DVAVFYLRGP SARLNFPDLL LQEEDHLSAA TTADMPAALI REKAAEVGAR
VDALLASAAP SMAHSTPPVI KPDLNQIPES GDI
