ID   RAPA_BACSU              Reviewed;         378 AA.
AC   Q00828; O34473;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Response regulator aspartate phosphatase A;
DE            EC=3.1.-.-;
DE   AltName: Full=Glucose starvation-inducible protein A;
DE   AltName: Full=Stage 0 sporulation protein L;
GN   Name=rapA; Synonyms=gsiAA, spo0L; OrderedLocusNames=BSU12430;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=1378051; DOI=10.1128/jb.174.13.4361-4373.1992;
RA   Mueller J.P., Bukusoglu G., Sonenshein A.L.;
RT   "Transcriptional regulation of Bacillus subtilis glucose starvation-
RT   inducible genes: control of gsiA by the ComP-ComA signal transduction
RT   system.";
RL   J. Bacteriol. 174:4361-4373(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   da Silva E., Karamata D.;
RT   "Sequencing and characterisation of the region comprising XlyB, the second
RT   lytic enzyme of the defective prophage PBSX of Bacillus subtilis.";
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-211.
RC   STRAIN=168;
RX   PubMed=9579062; DOI=10.1099/00221287-144-4-877;
RA   Rivolta C., Soldo B., Lazarevic V., Joris B., Mauel C., Karamata D.;
RT   "A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a
RT   putative 12.3 kb operon involved in hexuronate catabolism and a perfectly
RT   symmetrical hypothetical catabolite-responsive element.";
RL   Microbiology 144:877-884(1998).
RN   [5]
RP   FUNCTION.
RX   PubMed=1624431; DOI=10.1128/jb.174.13.4374-4383.1992;
RA   Mueller J.P., Sonenshein A.L.;
RT   "Role of the Bacillus subtilis gsiA gene in regulation of early sporulation
RT   gene expression.";
RL   J. Bacteriol. 174:4374-4383(1992).
CC   -!- FUNCTION: Prevents sporulation by dephosphorylating Spo0F.
CC       {ECO:0000269|PubMed:1624431}.
CC   -!- INDUCTION: Under all conditions of nutrient limitation, and by addition
CC       of decoyinine.
CC   -!- SIMILARITY: Belongs to the RAP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA40007.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X56679; CAA40007.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF034138; AAB87511.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13100.1; -; Genomic_DNA.
DR   EMBL; AF015825; AAC46339.1; -; Genomic_DNA.
DR   PIR; D69688; D69688.
DR   RefSeq; NP_389125.1; NC_000964.3.
DR   RefSeq; WP_010886491.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; Q00828; -.
DR   SMR; Q00828; -.
DR   IntAct; Q00828; 3.
DR   STRING; 224308.BSU12430; -.
DR   PaxDb; Q00828; -.
DR   PRIDE; Q00828; -.
DR   EnsemblBacteria; CAB13100; CAB13100; BSU_12430.
DR   GeneID; 939417; -.
DR   KEGG; bsu:BSU12430; -.
DR   PATRIC; fig|224308.43.peg.1306; -.
DR   eggNOG; COG0457; Bacteria.
DR   InParanoid; Q00828; -.
DR   OMA; YPYVEEL; -.
DR   PhylomeDB; Q00828; -.
DR   BioCyc; BSUB:BSU12430-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase; Reference proteome; Repeat; Sporulation;
KW   TPR repeat.
FT   CHAIN           1..378
FT                   /note="Response regulator aspartate phosphatase A"
FT                   /id="PRO_0000106435"
FT   REPEAT          101..137
FT                   /note="TPR 1"
FT   REPEAT          148..181
FT                   /note="TPR 2"
FT   REPEAT          183..215
FT                   /note="TPR 3"
FT   REPEAT          222..255
FT                   /note="TPR 4"
FT   REPEAT          261..294
FT                   /note="TPR 5"
FT   REPEAT          336..369
FT                   /note="TPR 6"
FT   CONFLICT        162
FT                   /note="S -> T (in Ref. 1; CAA40007)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   378 AA;  44974 MW;  8712FE59B865AEF4 CRC64;
     MRMKQTIPSS YVGLKINEWY THIRQFHVAE AERVKLEVER EIEDMEEDQD LLLYYSLMEF
     RHRVMLDYIK PFGEDTSQLE FSELLEDIEG NQYKLTGLLE YYFNFFRGMY EFKQKMFVSA
     MMYYKRAEKN LALVSDDIEK AEFAFKMAEI FYNLKQTYVS MSYAVQALET YQMYETYTVR
     RIQCEFVIAG NYDDMQYPER ALPHLELALD LAKKEGNPRL ISSALYNLGN CYEKMGELQK
     AAEYFGKSVS ICKSEKFDNL PHSIYSLTQV LYKQKNDAEA QKKYREGLEI ARQYSDELFV
     ELFQFLHALY GKNIDTESVS HTFQFLEEHM LYPYIEELAH DAAQFYIENG QPEKALSFYE
     KMVHAQKQIQ RGDCLYEI