ID   RAPE_BACSU              Reviewed;         375 AA.
AC   P45943;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Response regulator aspartate phosphatase E;
DE            EC=3.1.-.-;
GN   Name=rapE; Synonyms=yqcH; OrderedLocusNames=BSU25830;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=7704261; DOI=10.1099/13500872-141-2-323;
RA   Takemaru K., Mizuno M., Sato T., Takeuchi M., Kobayashi Y.;
RT   "Complete nucleotide sequence of a skin element excised by DNA
RT   rearrangement during sporulation in Bacillus subtilis.";
RL   Microbiology 141:323-327(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / JH642;
RX   PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA   Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA   Kobayashi Y.;
RT   "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT   Bacillus subtilis genome containing the skin element and many sporulation
RT   genes.";
RL   Microbiology 142:3103-3111(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   SEQUENCE REVISION TO 275.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=7489895; DOI=10.1016/0378-1119(95)00636-k;
RA   Medigue C., Moszer I., Viari A., Danchin A.;
RT   "Analysis of a Bacillus subtilis genome fragment using a co-operative
RT   computer system prototype.";
RL   Gene 165:GC37-GC51(1995).
CC   -!- SIMILARITY: Belongs to the RAP family. {ECO:0000305}.
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DR   EMBL; D32216; BAA06965.1; -; Genomic_DNA.
DR   EMBL; D84432; BAA12429.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14524.2; -; Genomic_DNA.
DR   PIR; H69688; H69688.
DR   RefSeq; NP_390460.2; NC_000964.3.
DR   RefSeq; WP_004398842.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P45943; -.
DR   SMR; P45943; -.
DR   STRING; 224308.BSU25830; -.
DR   PaxDb; P45943; -.
DR   PRIDE; P45943; -.
DR   EnsemblBacteria; CAB14524; CAB14524; BSU_25830.
DR   GeneID; 937796; -.
DR   KEGG; bsu:BSU25830; -.
DR   PATRIC; fig|224308.179.peg.2807; -.
DR   eggNOG; COG0457; Bacteria.
DR   InParanoid; P45943; -.
DR   OMA; HQAEEKN; -.
DR   PhylomeDB; P45943; -.
DR   BioCyc; BSUB:BSU25830-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Hydrolase; Protein phosphatase; Reference proteome; Repeat;
KW   TPR repeat.
FT   CHAIN           1..375
FT                   /note="Response regulator aspartate phosphatase E"
FT                   /id="PRO_0000106439"
FT   REPEAT          96..129
FT                   /note="TPR 1"
FT   REPEAT          177..210
FT                   /note="TPR 2"
FT   REPEAT          219..252
FT                   /note="TPR 3"
FT   REPEAT          258..291
FT                   /note="TPR 4"
FT   REPEAT          297..330
FT                   /note="TPR 5"
FT   REPEAT          333..366
FT                   /note="TPR 6"
FT   COILED          24..95
FT                   /evidence="ECO:0000255"
FT   CONFLICT        275
FT                   /note="E -> G (in Ref. 1; BAA06965 and 2; BAA12429)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   375 AA;  44636 MW;  B0F1731602789EFE CRC64;
     MISITSAEVG MKINEWHRHI QKFNVTDAEM LKAEIERDIE VMEEDQDLLI YYQLMAFRHK
     IMLEYTLPSD ENRMELSEYL NKIEGHKKKL DNMRAYYYNF FRGMYEFRNG EYTRAITYYK
     KAERKIPTIS DKIEKAEFYF KLSEVYYHMK MTHISMHYAE LSYNIYKKHE LYSVRRIQCH
     FVIAGNYDDL ENHEKALPHL QEALKGAELL KSKNTHIYAT AFFNLGNCYH KMDNLNKAAR
     YIEQALVQYR KINSDVLPQA YHDLALIYFK QGKKEQAMDC FRKGIRSAVD FKDELFMNLF
     EALDVLYIRN GDTPKLLNIF SRLENGKGYP YLEELALLGG NLFDYNGKIE DSIICFKKMV
     YAQKQISKGE CMYEI