RAPH_BACSU
ID RAPH_BACSU Reviewed; 376 AA.
AC Q59HN8; O31508; P40771;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Response regulator aspartate phosphatase H;
DE EC=3.1.-.-;
DE AltName: Full=PSP28;
GN Name=rapH; Synonyms=yeeH, yzqA; OrderedLocusNames=BSU06830;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP SEQUENCE REVISION TO C-TERMINUS.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-376, AND INDUCTION.
RC STRAIN=168;
RX PubMed=16553878; DOI=10.1111/j.1365-2958.2006.05059.x;
RA Hayashi K., Kensuke T., Kobayashi K., Ogasawara N., Ogura M.;
RT "Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode
RT inhibitors of expression of the srfA operon.";
RL Mol. Microbiol. 59:1714-1729(2006).
CC -!- INTERACTION:
CC Q59HN8; P06628: spo0F; NbExp=2; IntAct=EBI-15913371, EBI-6418009;
CC -!- INDUCTION: Repressed by RghR. {ECO:0000269|PubMed:16553878}.
CC -!- SIMILARITY: Belongs to the RAP family. {ECO:0000305}.
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DR EMBL; AL009126; CAB12503.2; -; Genomic_DNA.
DR EMBL; AB207815; BAD91217.1; -; Genomic_DNA.
DR PIR; C69689; C69689.
DR RefSeq; NP_388565.2; NC_000964.3.
DR RefSeq; WP_003243267.1; NZ_JNCM01000032.1.
DR PDB; 3Q15; X-ray; 2.19 A; A/B=1-376.
DR PDBsum; 3Q15; -.
DR AlphaFoldDB; Q59HN8; -.
DR SMR; Q59HN8; -.
DR DIP; DIP-58964N; -.
DR IntAct; Q59HN8; 1.
DR STRING; 224308.BSU06830; -.
DR PaxDb; Q59HN8; -.
DR PRIDE; Q59HN8; -.
DR EnsemblBacteria; CAB12503; CAB12503; BSU_06830.
DR GeneID; 936065; -.
DR KEGG; bsu:BSU06830; -.
DR PATRIC; fig|224308.179.peg.742; -.
DR eggNOG; COG0457; Bacteria.
DR InParanoid; Q59HN8; -.
DR OMA; CIQEYTE; -.
DR PhylomeDB; Q59HN8; -.
DR BioCyc; BSUB:BSU06830-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Hydrolase; Protein phosphatase; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..376
FT /note="Response regulator aspartate phosphatase H"
FT /id="PRO_0000106442"
FT REPEAT 99..132
FT /note="TPR 1"
FT REPEAT 139..172
FT /note="TPR 2"
FT REPEAT 180..213
FT /note="TPR 3"
FT REPEAT 220..253
FT /note="TPR 4"
FT REPEAT 259..292
FT /note="TPR 5"
FT REPEAT 334..367
FT /note="TPR 6"
FT HELIX 7..22
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 26..39
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 40..42
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 47..65
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 79..87
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 88..90
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 91..111
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 115..126
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 127..131
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 135..151
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 155..170
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 176..192
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 196..212
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 216..233
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 236..253
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 255..257
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 258..271
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 275..288
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 297..308
FT /evidence="ECO:0007829|PDB:3Q15"
FT STRAND 309..311
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 314..326
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 330..346
FT /evidence="ECO:0007829|PDB:3Q15"
FT HELIX 350..370
FT /evidence="ECO:0007829|PDB:3Q15"
SQ SEQUENCE 376 AA; 44003 MW; 74FABAA843676A74 CRC64;
MSQAIPSSRV GVKINEWYKM IRQFSVPDAE ILKAEVEQDI QQMEEDQDLL IYYSLMCFRH
QLMLDYLEPG KTYGNRPTVT ELLETIETPQ KKLTGLLKYY SLFFRGMYEF DQKEYVEAIG
YYREAEKELP FVSDDIEKAE FHFKVAEAYY HMKQTHVSMY HILQALDIYQ NHPLYSIRTI
QSLFVIAGNY DDFKHYDKAL PHLEAALELA MDIQNDRFIA ISLLNIANSY DRSGDDQMAV
EHFQKAAKVS REKVPDLLPK VLFGLSWTLC KAGQTQKAFQ FIEEGLDHIT ARSHKFYKEL
FLFLQAVYKE TVDERKIHDL LSYFEKKNLH AYIEACARSA AAVFESSCHF EQAAAFYRKV
LKAQEDILKG ECLYAY
