ID   RARA_ECO57              Reviewed;         447 AA.
AC   P0AAZ6; P45526; P75833;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Replication-associated recombination protein A;
GN   Name=rarA; OrderedLocusNames=Z1238, ECs0977;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: DNA-dependent ATPase that plays important roles in cellular
CC       responses to stalled DNA replication processes.
CC       {ECO:0000250|UniProtKB:P0AAZ4}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE005174; AAG55379.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34400.1; -; Genomic_DNA.
DR   PIR; A99751; A99751.
DR   RefSeq; NP_309004.1; NC_002695.1.
DR   RefSeq; WP_000067755.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AAZ6; -.
DR   SMR; P0AAZ6; -.
DR   STRING; 155864.EDL933_1156; -.
DR   PRIDE; P0AAZ6; -.
DR   EnsemblBacteria; AAG55379; AAG55379; Z1238.
DR   EnsemblBacteria; BAB34400; BAB34400; ECs_0977.
DR   GeneID; 66670834; -.
DR   GeneID; 917730; -.
DR   KEGG; ece:Z1238; -.
DR   KEGG; ecs:ECs_0977; -.
DR   PATRIC; fig|386585.9.peg.1094; -.
DR   eggNOG; COG2256; Bacteria.
DR   HOGENOM; CLU_017985_0_3_6; -.
DR   OMA; RIILSQC; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR032423; AAA_assoc_2.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR021886; MgsA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF16193; AAA_assoc_2; 1.
DR   Pfam; PF12002; MgsA_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..447
FT                   /note="Replication-associated recombination protein A"
FT                   /id="PRO_0000168756"
FT   BINDING         57..64
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P0AAZ4"
SQ   SEQUENCE   447 AA;  49626 MW;  116ACBE38E4E4A3A CRC64;
     MSNLSLDFSD NTFQPLAARM RPENLAQYIG QQHLLAAGKP LPRAIEAGHL HSMILWGPPG
     TGKTTLAEVI ARYANADVER ISAVTSGVKE IREAIERARQ NRNAGRRTIL FVDEVHRFNK
     SQQDAFLPHI EDGTITFIGA TTENPSFELN SALLSRARVY LLKSLSTEDI EQVLTQAMED
     KTRGYGGQDI VLPDETRRAI AELVNGDARR ALNTLEMMAD MAEVDDSGKR VLKPELLTEI
     AGERSARFDN KGDRFYDLIS ALHKSVRGSA PDAALYWYAR IITAGGDPLY VARRCLAIAS
     EDVGNADPRA MQVAIAAWDC FTRVGPAEGE RAIAQAIVYL ACAPKSNAVY TAFKAALADA
     RERPDYDVPV HLRNAPTKLM KEMGYGQEYR YAHDEANAYA AGEVYFPPEI AQTRYYFPTN
     RGLEGKIGEK LAWLAEQDQN SPIKRYR