ID   RARD_ECOLI              Reviewed;         296 AA.
AC   P27844; Q2M8C4;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Protein RarD;
GN   Name=rarD; OrderedLocusNames=b3819, JW5589;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RA   Ohmori H.;
RL   Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=1379743; DOI=10.1126/science.1379743;
RA   Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome: DNA sequence of the region from
RT   84.5 to 86.5 minutes.";
RL   Science 257:771-778(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   SEQUENCE REVISION.
RX   PubMed=16397293; DOI=10.1093/nar/gkj405;
RA   Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA   Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA   Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA   Thomson N.R., Wishart D., Wanner B.L.;
RT   "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT   -- 2005.";
RL   Nucleic Acids Res. 34:1-9(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [6]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
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DR   EMBL; L02122; AAD15041.1; -; Genomic_DNA.
DR   EMBL; M87049; AAA67615.1; -; Genomic_DNA.
DR   EMBL; U00096; AAT48220.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77482.1; -; Genomic_DNA.
DR   PIR; S30709; S30709.
DR   PIR; S30746; S30746.
DR   RefSeq; WP_000339104.1; NZ_STEB01000021.1.
DR   RefSeq; YP_026262.1; NC_000913.3.
DR   AlphaFoldDB; P27844; -.
DR   SMR; P27844; -.
DR   BioGRID; 4261790; 13.
DR   IntAct; P27844; 1.
DR   STRING; 511145.b3819; -.
DR   TCDB; 2.A.7.7.2; the drug/metabolite transporter (dmt) superfamily.
DR   PaxDb; P27844; -.
DR   PRIDE; P27844; -.
DR   EnsemblBacteria; AAT48220; AAT48220; b3819.
DR   EnsemblBacteria; BAE77482; BAE77482; BAE77482.
DR   GeneID; 948330; -.
DR   KEGG; ecj:JW5589; -.
DR   KEGG; eco:b3819; -.
DR   PATRIC; fig|1411691.4.peg.2888; -.
DR   EchoBASE; EB1434; -.
DR   eggNOG; COG2962; Bacteria.
DR   HOGENOM; CLU_054508_1_0_6; -.
DR   InParanoid; P27844; -.
DR   OMA; HRMVWSL; -.
DR   PhylomeDB; P27844; -.
DR   BioCyc; EcoCyc:EG11466-MON; -.
DR   PRO; PR:P27844; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IDA:EcoCyc.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   InterPro; IPR000620; EamA_dom.
DR   InterPro; IPR004626; RarD.
DR   PANTHER; PTHR22911:SF114; PTHR22911:SF114; 1.
DR   Pfam; PF00892; EamA; 2.
DR   TIGRFAMs; TIGR00688; rarD; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..296
FT                   /note="Protein RarD"
FT                   /id="PRO_0000108152"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..37
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..99
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..149
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..211
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..270
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..296
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          18..145
FT                   /note="EamA"
FT   CONFLICT        102
FT                   /note="A -> R (in Ref. 2; AAA67615)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123..124
FT                   /note="ER -> DG (in Ref. 2; AAA67615)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   296 AA;  33283 MW;  E4E462C1E154912D CRC64;
     MDAKQTRQGV LLALAAYFIW GIAPAYFKLI YYVPADEILT HRVIWSFFFM VVLMSICRQW
     SYLKTLIQTP QKIFMLAVSA VLIGGNWLLF IWAVNNHHML EASLGYFINP LVNIVLGMIF
     LGERFRRMQW LAVILAICGV LVQLWTFGSL PIIALGLAFS FAFYGLVRKK IAVEAQTGML
     IETMWLLPVA AIYLFAIADS STSHMGQNPM SLNLLLIAAG IVTTVPLLCF TAAATRLRLS
     TLGFFQYIGP TLMFLLAVTF YGEKPGADKM VTFAFIWVAL AIFVMDAIYT QRRTSK