ATPA_LACSA
ID ATPA_LACSA Reviewed; 508 AA.
AC Q332Y4; Q56P06;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=ATP synthase subunit alpha, chloroplastic {ECO:0000255|HAMAP-Rule:MF_01346};
DE EC=7.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01346};
DE AltName: Full=ATP synthase F1 sector subunit alpha {ECO:0000255|HAMAP-Rule:MF_01346};
DE AltName: Full=F-ATPase subunit alpha {ECO:0000255|HAMAP-Rule:MF_01346};
GN Name=atpA {ECO:0000255|HAMAP-Rule:MF_01346}; ORFNames=PSC019;
OS Lactuca sativa (Garden lettuce).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC Lactucinae; Lactuca.
OX NCBI_TaxID=4236;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Cisco;
RX PubMed=16604461; DOI=10.1007/s11248-005-3997-2;
RA Kanamoto H., Yamashita A., Asao H., Okumura S., Takase H., Hattori M.,
RA Yokota A., Tomizawa K.;
RT "Efficient and stable transformation of Lactuca sativa L. cv. Cisco
RT (lettuce) plastids.";
RL Transgenic Res. 15:205-217(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Salinas;
RA Timme R.E., Kuehl J.V., Boore J.L., Jansen R.K.;
RT "A comparison of the first two published chloroplast genomes in Asteraceae:
RT Lactuca and Helianthus.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15917497; DOI=10.1093/molbev/msi174;
RA Kim K.-J., Choi K.-S., Jansen R.K.;
RT "Two chloroplast DNA inversions originated simultaneously during the early
RT evolution of the sunflower family (Asteraceae).";
RL Mol. Biol. Evol. 22:1783-1792(2005).
CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient
CC across the membrane. The alpha chain is a regulatory subunit.
CC {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate;
CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01346};
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main
CC subunits: a, b, b' and c. {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000255|HAMAP-Rule:MF_01346}; Peripheral membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC {ECO:0000255|HAMAP-Rule:MF_01346}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX58149.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP007232; BAE47588.1; -; Genomic_DNA.
DR EMBL; DQ383816; ABD47227.1; -; Genomic_DNA.
DR EMBL; AY865171; AAX58149.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; YP_398323.1; NC_007578.1.
DR AlphaFoldDB; Q332Y4; -.
DR SMR; Q332Y4; -.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_0X28780_mrna; cds-PLY91981.1; gene-LSAT_0X28780.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_1X38700_mrna; cds-PLY97261.1; gene-LSAT_1X38700.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_1X88060_mrna; cds-PLY71590.1; gene-LSAT_1X88060.
DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_8X122301_mrna; cds-PLY83516.1; gene-LSAT_8X122301.
DR GeneID; 3772896; -.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_0X28780_mrna; cds-PLY91981.1; gene-LSAT_0X28780.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_1X38700_mrna; cds-PLY97261.1; gene-LSAT_1X38700.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_1X88060_mrna; cds-PLY71590.1; gene-LSAT_1X88060.
DR Gramene; rna-gnl|WGS:NBSK|LSAT_8X122301_mrna; cds-PLY83516.1; gene-LSAT_8X122301.
DR KEGG; lsv:3772896; -.
DR OrthoDB; 470054at2759; -.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC.
DR CDD; cd18113; ATP-synt_F1_alpha_C; 1.
DR CDD; cd01132; F1_ATPase_alpha; 1.
DR Gene3D; 1.20.150.20; -; 1.
DR Gene3D; 2.40.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01346; ATP_synth_alpha_bact; 1.
DR InterPro; IPR023366; ATP_synth_asu-like_sf.
DR InterPro; IPR000793; ATP_synth_asu_C.
DR InterPro; IPR038376; ATP_synth_asu_C_sf.
DR InterPro; IPR033732; ATP_synth_F1_a.
DR InterPro; IPR005294; ATP_synth_F1_asu.
DR InterPro; IPR020003; ATPase_a/bsu_AS.
DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N.
DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf.
DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00006; ATP-synt_ab; 1.
DR Pfam; PF00306; ATP-synt_ab_C; 1.
DR Pfam; PF02874; ATP-synt_ab_N; 1.
DR PIRSF; PIRSF039088; F_ATPase_subunit_alpha; 1.
DR SUPFAM; SSF50615; SSF50615; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00962; atpA; 1.
DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW ATP synthesis; ATP-binding; CF(1); Chloroplast; Hydrogen ion transport;
KW Ion transport; Membrane; Nucleotide-binding; Plastid; Thylakoid;
KW Translocase; Transport.
FT CHAIN 1..508
FT /note="ATP synthase subunit alpha, chloroplastic"
FT /id="PRO_0000238425"
FT BINDING 170..177
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01346"
FT SITE 363
FT /note="Required for activity"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01346"
SQ SEQUENCE 508 AA; 55518 MW; 762D64A00DFA6412 CRC64;
MVTIQADEIS NIIRERIEQY NREVKIVNTG TVLQVGDGIA RIHGLDEVMA GELVEFEEGT
IGIALNLEST NVGVVLMGDG LLIQEGSSVK ATGRIAQIPV SEAYLGRVIN ALAKPIDGRG
EISSSEYRLI ESPAPGIISR RSVYEPLQTG LIAIDSMIPI GRGQRELIIG DRQTGKTAVA
TDTILNQQGK NVICVYVAIG QKASSVAQVV TNFQERGAME YTIVVAETAD SPATLQYLAP
YTGAALAEYF MYRERHTSII YDDPSKQAQA YRQMSLLLRR PPGREAYPGD VFYLHSRLLE
RAAKLSSLLG EGSMTALPIV ETQSGDVSAY IPTNVISITD GQIFLSADLF NAGIRPAINV
GISVSRVGSA AQIKAMKQVA GKLKLELAQF AELEAFAQFA SDLDKATQNQ LARGQRLREL
LKQSQSAPLG VEEQVLTIYT GTNGYLDSLE IGQVRKFLVE LRTYLKTNKP QFQEIISSTK
TFTEEAEAIL KEAIKEQRER FILQEQAA
